InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dpp6

Summary

InnateDB Gene

IDBG-143778.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dpp6

Gene Name

dipeptidylpeptidase 6

Synonyms

B930011P16Rik; D5Buc3; D5Buc4; D5Buc5; DPP VI; Dpp-6; Gm1377; In(5)6H-p; Peplb; Rw

Species

Mus musculus

Ensembl Gene

ENSMUSG00000061576

Encoded Proteins

IDBP-143780

dipeptidylpeptidase 6

IDBP-143782

dipeptidylpeptidase 6

IDBP-401344

dipeptidylpeptidase 6

IDBP-401343

dipeptidylpeptidase 6

IDBP-532273

dipeptidylpeptidase 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130226:
This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:26817203-27727505

Strand

Forward strand

Band

Transcripts

ENSMUST00000071500	ENSMUSP00000071435
ENSMUST00000101471	ENSMUSP00000099012
ENSMUST00000120555	ENSMUSP00000113849
ENSMUST00000122171	ENSMUSP00000113441
ENSMUST00000149678
ENSMUST00000136574
ENSMUST00000148039	ENSMUSP00000115944
ENSMUST00000134175

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0019228	neuronal action potential
GO:0042391	regulation of membrane potential
GO:0043266	regulation of potassium ion transport
GO:1901379	regulation of potassium ion transmembrane transport
GO:1901381	positive regulation of potassium ion transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000130226

View Gene Order

ENSBTAG00000021941

Not yet available

Cross-References

SwissProt

Q9Z218

TrEMBL

D6RFR3 E9PWX1 Q5U4C2 Q80VM5

UniProt Splice Variant

Entrez Gene

13483

UniGene

Mm.408949 Mm.42078

RefSeq

NM_001136060 NM_001198886 NM_010075 NM_207282 XM_006535627

OMIM

CCDS

CCDS19139 CCDS51446 CCDS51447 CCDS57332

HPRD

IMGT

MGI ID

MGI:94921

MGI Symbol

Dpp6

EMBL

AC104101 AC122221 AC123063 AC124703 AC129015 AC140218 AC146612 AC147555 AF092505 AF092506 AF092507 BC048383 BC085154

GenPept

AAC97365 AAC97366 AAC98381 AAH48383 AAH85154

RNA Seq Atlas

13483