Version 5.4
Mus musculus Gene: Ap1b1
Summary
InnateDB Gene IDBG-143791.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ap1b1
Gene Name adaptor protein complex AP-1, beta 1 subunit
Synonyms Adtb1; b2b1660Clo
Species Mus musculus
Ensembl Gene ENSMUSG00000009090
Encoded Proteins
IDBP-143795
adaptor protein complex AP-1, beta 1 subunit
IDBP-143797
adaptor protein complex AP-1, beta 1 subunit
IDBP-261409
adaptor protein complex AP-1, beta 1 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100280:
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:4986824-5042791
Strand Forward strand
Band A1
Transcripts
ENSMUST00000009234 ENSMUSP00000009234
ENSMUST00000101613 ENSMUSP00000099134
ENSMUST00000109897 ENSMUSP00000105523
ENSMUST00000137292
ENSMUST00000133014
ENSMUST00000144426
ENSMUST00000145704
ENSMUST00000142325
ENSMUST00000133007
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008565 protein transporter activity
Biological Process
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005802 trans-Golgi network
GO:0030117 membrane coat
GO:0030131 clathrin adaptor complex
GO:0030665 clathrin-coated vesicle membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100280
View Gene Order
ENSBTAG00000001189
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_231722
Lysosome Vesicle Biogenesis pathway
REACT_230745
Immune System pathway
REACT_232671
Golgi Associated Vesicle Biogenesis pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_234979
Clathrin derived vesicle budding pathway
REACT_229531
Adaptive Immune System pathway
KEGG
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_11103
Nef mediated downregulation of MHC class I complex cell surface expression pathway
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_6185
HIV Infection pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
hnf3apathway
FOXA1 transcription factor network
Cross-References
SwissProt
TrEMBL Q5SVG5
UniProt Splice Variant
Entrez Gene 11764
UniGene Mm.274816 Mm.397718 Mm.487272
RefSeq NM_001243043 NM_001243044 NM_007454 XM_006514461 XM_006514462 XM_006514463
OMIM
CCDS CCDS36100
HPRD
IMGT
MGI ID MGI:1096368
MGI Symbol Ap1b1
EMBL AL645522
GenPept
RNA Seq Atlas 11764

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca