Version 5.4
| Mus musculus Gene: Eif3j2 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-143864.7 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Eif3j2 | ||||||||
| Gene Name | eukaryotic translation initiation factor 3, subunit J2 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000043424 | ||||||||
| Encoded Proteins |
predicted gene 9781
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104131:
Eukaryotic initiation factor-3 (EIF3) has a molecular mass of about 600 kD and contains 13 nonidentical protein subunits, including EIF3J. EIF3 plays a central role in binding of initiator methionyl-tRNA and mRNA to the 40S ribosomal subunit to form the 40S initiation complex (Fraser et al., 2004 [PubMed 14688252]; Fraser et al., 2007 [PubMed 17588516]).[supplied by OMIM, Mar 2008] This gene encodes a core subunit of the eukaryotic initiation factor 3 complex, which participates in the initiation of translation by aiding in the recruitment of protein and mRNA components to the 40S ribosome. There are pseudogenes for this gene on chromosomes 1, 3, and 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 18:43475418-43477796 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | B3 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME |
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Translation pathway
Translation initiation complex formation pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Eukaryotic Translation Initiation pathway
Formation of a pool of free 40S subunits pathway
Gene Expression pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Ribosomal scanning and start codon recognition pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Formation of the ternary complex, and subsequently, the 43S complex pathway
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| KEGG |
RNA transport pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
L13a-mediated translational silencing of Ceruloplasmin expression pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Translation initiation complex formation pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Formation of a pool of free 40S subunits pathway
Formation of the ternary complex, and subsequently, the 43S complex pathway
Ribosomal scanning and start codon recognition pathway
Eukaryotic Translation Initiation pathway
Translation pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Gene Expression pathway
Formation of the ternary complex, and subsequently, the 43S complex pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Gene Expression pathway
Eukaryotic Translation Initiation pathway
Cap-dependent Translation Initiation pathway
Formation of a pool of free 40S subunits pathway
Translation pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Metabolism of proteins pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Translation initiation complex formation pathway
Ribosomal scanning and start codon recognition pathway
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| KEGG |
RNA transport pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | Q66JS6 | ||||||||
| TrEMBL | Q2YDW1 Q66JW9 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 100042807 | ||||||||
| UniGene | Mm.329403 Mm.483268 Mm.489777 | ||||||||
| RefSeq | NM_001256055 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS57122 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:3704486 | ||||||||
| MGI Symbol | Eif3j2 | ||||||||
| EMBL | AK082048 BC080724 BC080788 BC108355 | ||||||||
| GenPept | AAH80724 AAH80788 AAI08356 BAC38399 | ||||||||
| RNA Seq Atlas | 100042807 | ||||||||