InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: En2

Summary

InnateDB Gene

IDBG-144062.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

En2

Gene Name

engrailed 2

Synonyms

BB131122; En-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039095

Encoded Proteins

IDBP-144064

engrailed 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164778:
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the \'engrailed\' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:28165694-28172166

Strand

Forward strand

Band

Transcripts

ENSMUST00000036177

ENSMUSP00000036761

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0030182	neuron differentiation
GO:0030901	midbrain development
GO:0030902	hindbrain development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048666	neuron development

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000164778

View Gene Order

ENSBTAG00000018917

Not yet available

Cross-References

SwissProt

P09066

TrEMBL

Q3TZM2

UniProt Splice Variant

Entrez Gene

13799

UniGene

Mm.4298

RefSeq

NM_010134

OMIM

CCDS

CCDS19143

HPRD

IMGT

MGI ID

MGI:95390

MGI Symbol

En2

EMBL

AK157766 CH466524 L12704 L12705 Y00203

GenPept

AAA53527 BAE34186 CAA68362 EDL37227

RNA Seq Atlas

13799