InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Exosc3

Summary

InnateDB Gene

IDBG-144083.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Exosc3

Gene Name

exosome component 3

Synonyms

2310005D06Rik; AI593501; Rrp40

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028322

Encoded Proteins

IDBP-144085

exosome component 3

IDBP-533819

exosome component 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107371:
This gene encodes a non-catalytic component of the human exosome, a complex with 3'-5' exoribonuclease activity that plays a role in numerous RNA processing and degradation activities. Related pseudogenes of this gene are found on chromosome 19 and 21. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:45316613-45342732

Strand

Reverse strand

Band

Transcripts

ENSMUST00000030003	ENSMUSP00000030003
ENSMUST00000143111
ENSMUST00000152056	ENSMUSP00000115532
ENSMUST00000130843

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003723	RNA binding
GO:0004527	exonuclease activity
GO:0005515	protein binding

Biological Process

GO:0006364	rRNA processing
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0045006	DNA deamination
GO:0045190	isotype switching
GO:0045830	positive regulation of isotype switching
GO:0071034	CUT catabolic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0000176	nuclear exosome (RNase complex)
GO:0000177	cytoplasmic exosome (RNase complex)
GO:0000178	exosome (RNase complex)
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0035327	transcriptionally active chromatin