Version 5.4
Mus musculus Gene: Marcks
Summary
InnateDB Gene IDBG-144103.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Marcks
Gene Name myristoylated alanine rich protein kinase C substrate
Synonyms Macs; PKCSL
Species Mus musculus
Ensembl Gene ENSMUSG00000069662
Encoded Proteins
IDBP-144105
myristoylated alanine rich protein kinase C substrate
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:37133375-37138920
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000092584 ENSMUSP00000090245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005938 cell cortex
GO:0016020 membrane
GO:0042585 germinal vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
null
View Gene Order
ENSBTAG00000002082
Not yet available
Pathways
NETPATH
REACTOME
REACT_217323
Integration of energy metabolism pathway
REACT_247495
Acetylcholine regulates insulin secretion pathway
REACT_188937
Metabolism pathway
REACT_263148
Regulation of insulin secretion pathway
KEGG
mmu04666
Fc gamma R-mediated phagocytosis pathway
INOH
PID NCI
Cross-References
SwissProt P26645
TrEMBL Q05BL6
UniProt Splice Variant
Entrez Gene 17118
UniGene Mm.30059 Mm.402667 Mm.409583 Mm.485179
RefSeq NM_008538
OMIM
CCDS CCDS23784
HPRD
IMGT
MGI ID MGI:96907
MGI Symbol Marcks
EMBL BC039911 BC046601 M60474
GenPept AAA39491 AAH39911 AAH46601
RNA Seq Atlas 17118

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca