InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bag4

Summary

InnateDB Gene

IDBG-144400.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bag4

Gene Name

BCL2-associated athanogene 4

Synonyms

2410112I15Rik; SODD

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037316

Encoded Proteins

IDBP-144402

BCL2-associated athanogene 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156735:
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:25764538-25785209

Strand

Reverse strand

Band

Transcripts

ENSMUST00000038498

ENSMUSP00000044725

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0051087	chaperone binding

Biological Process

GO:0006915	apoptotic process
GO:0010763	positive regulation of fibroblast migration
GO:0030838	positive regulation of actin filament polymerization
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0042981	regulation of apoptotic process
GO:0045785	positive regulation of cell adhesion
GO:0051291	protein heterooligomerization
GO:0051496	positive regulation of stress fiber assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0071356	cellular response to tumor necrosis factor
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0072659	protein localization to plasma membrane
GO:0090367	negative regulation of mRNA modification
GO:0097178	ruffle assembly
GO:2001145	negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000156735

View Gene Order

ENSBTAG00000013143

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

INOH

PID NCI

ceramide_pathway

Ceramide signaling pathway

tnfpathway

TNF receptor signaling pathway

hivnefpathway

HIV-1 Nef: Negative effector of Fas and TNF-alpha

Cross-References

SwissProt

Q8CI61

TrEMBL

A6H6S8

UniProt Splice Variant

Entrez Gene

67384

UniGene

Mm.118400 Mm.395871

RefSeq

NM_026121

OMIM

CCDS

CCDS22201

HPRD

IMGT

MGI ID

MGI:1914634

MGI Symbol

Bag4

EMBL

AF332863 AK010765 AK136899 AK162658 BC009102 BC037239 BC058518 BC138201 BC145986 CH466580

GenPept

AAH09102 AAH37239 AAH58518 AAI38202 AAI45987 AAL99586 BAB27167 BAE23161 BAE37009 EDL32822

RNA Seq Atlas

67384