Version 5.4
Mus musculus Gene: Kremen1
Summary
InnateDB Gene IDBG-144616.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kremen1
Gene Name kringle containing transmembrane protein 1
Synonyms AV002070; Kremen; Krm1
Species Mus musculus
Ensembl Gene ENSMUSG00000020393
Encoded Proteins
IDBP-144618
kringle containing transmembrane protein 1
IDBP-538493
kringle containing transmembrane protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183762:
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:5191552-5261558
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000020662 ENSMUSP00000020662
ENSMUST00000151978 ENSMUSP00000121252
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006952 defense response
GO:0008150 biological_process
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000183762
View Gene Order
ENSBTAG00000009773
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_8
Wnt pathway
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_200643
negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL Q8BNJ0
UniProt Splice Variant
Entrez Gene 84035
UniGene Mm.209989
RefSeq NM_032396
OMIM
CCDS CCDS24399
HPRD
IMGT
MGI ID MGI:1933988
MGI Symbol Kremen1
EMBL AK083565
GenPept BAC38952
RNA Seq Atlas 84035

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca