Version 5.4
Mus musculus Gene: Ncbp1
Summary
InnateDB Gene IDBG-144836.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ncbp1
Gene Name nuclear cap binding protein subunit 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000028330
Encoded Proteins
IDBP-144838
nuclear cap binding protein subunit 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136937:
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008]
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5\' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3\'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:46138613-46172403
Strand Forward strand
Band B1
Transcripts
ENSMUST00000030014 ENSMUSP00000030014
ENSMUST00000131187
ENSMUST00000133286
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 54 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000339 RNA cap binding
GO:0003723 RNA binding
GO:0005488 binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006370 7-methylguanosine mRNA capping
GO:0006379 mRNA cleavage
GO:0006406 mRNA export from nucleus
GO:0006446 regulation of translational initiation
GO:0016070 RNA metabolic process
GO:0031047 gene silencing by RNA
GO:0031442 positive regulation of mRNA 3'-end processing
GO:0045292 mRNA cis splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005845 mRNA cap binding complex
GO:0005846 nuclear cap binding complex
GO:0005886 plasma membrane
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000136937
View Gene Order
ENSBTAG00000009732
Not yet available
Pathways
NETPATH
REACTOME
REACT_240247
mRNA 3'-end processing pathway
REACT_203462
Formation of the Early Elongation Complex pathway
REACT_237682
Transport of Mature Transcript to Cytoplasm pathway
REACT_249110
mRNA Splicing pathway
REACT_215668
SLBP independent Processing of Histone Pre-mRNAs pathway
REACT_235610
mRNA Splicing - Minor Pathway pathway
REACT_248407
Processing of Capped Intronless Pre-mRNA pathway
REACT_224866
Metabolism of non-coding RNA pathway
REACT_198522
Nonsense-Mediated Decay (NMD) pathway
REACT_226759
Formation of RNA Pol II elongation complex pathway
REACT_198528
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_198524
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
REACT_232123
Processing of Intronless Pre-mRNAs pathway
REACT_257346
RNA Polymerase II Transcription Termination pathway
REACT_226490
RNA Polymerase II Transcription Elongation pathway
REACT_253727
Cleavage of Growing Transcript in the Termination Region pathway
REACT_255009
RNA Polymerase II Pre-transcription Events pathway
REACT_206812
snRNP Assembly pathway
REACT_258231
mRNA Capping pathway
REACT_233572
Gene Expression pathway
REACT_212343
Transport of the SLBP independent Mature mRNA pathway
REACT_235695
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs pathway
REACT_260226
mRNA Splicing - Major Pathway pathway
REACT_244199
Transport of Mature mRNA Derived from an Intronless Transcript pathway
REACT_250734
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
REACT_232353
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_239127
Transport of the SLBP Dependant Mature mRNA pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_242255
RNA Polymerase II Transcription pathway
KEGG
mmu03040
Spliceosome pathway
mmu03013
RNA transport pathway
mmu03015
mRNA surveillance pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11066
snRNP Assembly pathway
REACT_75768
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
REACT_75822
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_185
SLBP independent Processing of Histone Pre-mRNAs pathway
REACT_1096
Processing of Intronless Pre-mRNAs pathway
REACT_1364
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs pathway
REACT_1849
mRNA 3'-end processing pathway
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_1753
mRNA Splicing - Minor Pathway pathway
REACT_1597
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_424
Transport of the SLBP independent Mature mRNA pathway
REACT_405
Transport of the SLBP Dependant Mature mRNA pathway
REACT_1835
Transport of Mature mRNA Derived from an Intronless Transcript pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1470
mRNA Capping pathway
REACT_387
Cleavage of Growing Transcript in the Termination Region pathway
REACT_22107
RNA Polymerase II Pre-transcription Events pathway
REACT_1845
Formation of RNA Pol II elongation complex pathway
REACT_846
Formation of the Early Elongation Complex pathway
REACT_833
RNA Polymerase II Transcription Elongation pathway
REACT_22201
Formation of HIV elongation complex in the absence of HIV Tat pathway
REACT_6319
Formation of the HIV-1 Early Elongation Complex pathway
REACT_6346
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
REACT_6162
Tat-mediated elongation of the HIV-1 transcript pathway
REACT_6261
Abortive elongation of HIV-1 transcript in the absence of Tat pathway
REACT_6233
Transcription of the HIV genome pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_75886
Nonsense-Mediated Decay (NMD) pathway
REACT_894
RNA Polymerase II Transcription Termination pathway
REACT_6274
HIV Transcription Elongation pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_1281
Transport of Mature Transcript to Cytoplasm pathway
REACT_6256
HIV Life Cycle pathway
REACT_11052
Metabolism of non-coding RNA pathway
REACT_1768
Processing of Capped Intronless Pre-mRNA pathway
REACT_338
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
REACT_6185
HIV Infection pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
KEGG
hsa03040
Spliceosome pathway
hsa03013
RNA transport pathway
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q3UYV9
TrEMBL
UniProt Splice Variant
Entrez Gene 433702
UniGene Mm.389536
RefSeq NM_001033201
OMIM
CCDS CCDS18145
HPRD
IMGT
MGI ID MGI:1891840
MGI Symbol Ncbp1
EMBL AK134334 AK169557 AL732615 AL929438 BC055777 BC138898 CH466565
GenPept AAH55777 AAI38899 BAE22102 BAE41227 CAM14995 CAM17033 EDL02380
RNA Seq Atlas 433702

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca