Version 5.4
Mus musculus Gene: Cox5b
Summary
InnateDB Gene IDBG-144958.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cox5b
Gene Name cytochrome c oxidase, subunit Vb
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000061518
Encoded Proteins
IDBP-144960
cytochrome c oxidase, subunit Vb
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 23308066
[Homo sapiens] COX5B coordinates with the autophagy pathway to control MAVS aggregation and antiviral signalling.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135940:
Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:36691487-36693385
Strand Forward strand
Band B
Transcripts
ENSMUST00000081180 ENSMUSP00000079944
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004129 cytochrome-c oxidase activity
Biological Process
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005740 mitochondrial envelope
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000135940
View Gene Order
ENSBTAG00000018542
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00190
Oxidative phosphorylation pathway
mmu05010
Alzheimer's disease pathway
mmu05012
Parkinson's disease pathway
mmu04260
Cardiac muscle contraction pathway
mmu05016
Huntington's disease pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_22393
Respiratory electron transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_6305
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_267716
Orphan transporters pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
REACT_271057
Orphan transporters pathway
REACT_215469
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_223103
Transmembrane transport of small molecules pathway
REACT_218878
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_219139
Metabolism pathway
REACT_223064
Respiratory electron transport pathway
KEGG
hsa05010
Alzheimer's disease pathway
hsa00190
Oxidative phosphorylation pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
hsa04260
Cardiac muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q9D881
UniProt Splice Variant
Entrez Gene 12859
UniGene
RefSeq NM_009942 XM_006542973
OMIM
CCDS CCDS14886
HPRD
IMGT
MGI ID MGI:88475
MGI Symbol Cox5b
EMBL AC084389 AK008339 AK131673 AK135174 AL589742 BC096048 BC099474 CH466536 CH466561
GenPept AAH96048 AAH99474 BAB25614 BAE20757 BAE22451 EDL14503 EDL32647
RNA Seq Atlas 102638382 102641600 12859

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca