Version 5.4
Mus musculus Gene: Hook3
Summary
InnateDB Gene IDBG-145033.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hook3
Gene Name hook homolog 3 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000037234
Encoded Proteins
IDBP-145035
hook homolog 3 (Drosophila)
IDBP-535080
hook homolog 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168172:
Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:26021421-26119224
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000037182 ENSMUSP00000046788
ENSMUST00000147613 ENSMUSP00000115008
ENSMUST00000152144
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0042802 identical protein binding
Biological Process
GO:0007032 endosome organization
GO:0007040 lysosome organization
GO:0008333 endosome to lysosome transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0022027 interkinetic nuclear migration
GO:0031122 cytoplasmic microtubule organization
GO:0034454 microtubule anchoring at centrosome
GO:0045022 early endosome to late endosome transport
GO:0050768 negative regulation of neurogenesis
GO:0051645 Golgi localization
GO:0071539 protein localization to centrosome
GO:0097150 neuronal stem cell maintenance
Cellular Component
GO:0000242 pericentriolar material
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005801 cis-Golgi network
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005874 microtubule
GO:0016020 membrane
GO:0030897 HOPS complex
GO:0034451 centriolar satellite
GO:0070695 FHF complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000168172
View Gene Order
ENSBTAG00000007634
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 320191
UniGene Mm.334464 Mm.409939 Mm.412998 Mm.458186 Mm.473202 Mm.473444 Mm.487556
RefSeq NM_207659 XM_006509148 XM_006509151
OMIM
CCDS CCDS22206
HPRD
IMGT
MGI ID MGI:2443554
MGI Symbol Hook3
EMBL
GenPept
RNA Seq Atlas 320191

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca