InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHD4

Summary

InnateDB Gene

IDBG-14532.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHD4

Gene Name

chromodomain helicase DNA binding protein 4

Synonyms

CHD-4; Mi-2b; Mi2-BETA

Species

Homo sapiens

Ensembl Gene

ENSG00000111642

Encoded Proteins

IDBP-14536

chromodomain helicase DNA binding protein 4

IDBP-586794

chromodomain helicase DNA binding protein 4

IDBP-599167

chromodomain helicase DNA binding protein 4

IDBP-588522

chromodomain helicase DNA binding protein 4

IDBP-597474

chromodomain helicase DNA binding protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. [provided by RefSeq, Jul 2008]
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:6570083-6607476

Strand

Reverse strand

Band

p13.31

Transcripts

ENST00000357008	ENSP00000349508
ENST00000430771
ENST00000544484	ENSP00000440392
ENST00000544040	ENSP00000440542
ENST00000535717
ENST00000542717
ENST00000536301
ENST00000540960
ENST00000537634
ENST00000545083
ENST00000536999
ENST00000535810
ENST00000545942	ENSP00000437506
ENST00000545584	ENSP00000444614

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 115 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	115 [view]
Protein-Protein	115 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008026	ATP-dependent helicase activity
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0031492	nucleosomal DNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008152	metabolic process
GO:0032508	DNA duplex unwinding
GO:0043044	ATP-dependent chromatin remodeling
GO:0051225	spindle assembly

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0016020	membrane
GO:0016581	NuRD complex
GO:0043234	protein complex