Version 5.4
Mus musculus Gene: Atg12
Summary
InnateDB Gene IDBG-145432.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atg12
Gene Name autophagy related 12
Synonyms 4931423H11Rik; A330058M13Rik; Apg12l; Atg12l
Species Mus musculus
Ensembl Gene ENSMUSG00000032905
Encoded Proteins
IDBP-145434
autophagy-related 12 (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17921696
Atg12::Atg5 conjugate is a key regulator of the autophagic process to eliminate pathogens such as Streptococcus, M. tuberculosis, Listeria, and herpesvirus. Atg12::Atg5 also associates with components of the RIG-I pathway to negatively regulate type I IFN response and promote RNA virus replication.
InnateDB Annotation from Orthologs
Summary
PMID 17921696
[Homo sapiens] ATG12::ATG5 conjugate is a key regulator of the autophagic process to eliminate pathogens such as Streptococcus, M. tuberculosis, Listeria, and herpesvirus. ATG12::ATG5 also associates with components of the RIG-I pathway to negatively regulate type I IFN response and promote RNA virus replication.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145782:
Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:46732417-46741579
Strand Reverse strand
Band C
Transcripts
ENSMUST00000035648 ENSMUSP00000038489
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 65 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0006914 autophagy
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0034045 pre-autophagosomal structure membrane
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145782
View Gene Order
ENSBTAG00000017525
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_198532
Negative regulators of RIG-I/MDA5 signaling pathway
REACT_230745
Immune System pathway
REACT_219118
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
KEGG
mmu04140
Regulation of autophagy pathway
mmu04622
RIG-I-like receptor signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25271
Negative regulators of RIG-I/MDA5 signaling pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04140
Regulation of autophagy pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q9CQY1
TrEMBL
UniProt Splice Variant
Entrez Gene 67526
UniGene Mm.399737 Mm.9852
RefSeq NM_026217
OMIM
CCDS CCDS37811
HPRD
IMGT
MGI ID MGI:1914776
MGI Symbol Atg12
EMBL AB066216 AK005405 AK008698 AK016474 AK167027 BC070470
GenPept AAH70470 BAB24005 BAB25839 BAB30256 BAB62092 BAE39200
RNA Seq Atlas 67526

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca