InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gck

Summary

InnateDB Gene

IDBG-145703.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gck

Gene Name

glucokinase

Synonyms

Gk; GLK; Gls006; HK4; HKIV; HXKP; MODY2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041798

Encoded Proteins

IDBP-145705

glucokinase

IDBP-261565

glucokinase

IDBP-261567

glucokinase

IDBP-540309

glucokinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106633:
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:5900820-5950081

Strand

Reverse strand

Band

Transcripts

ENSMUST00000102920	ENSMUSP00000099984
ENSMUST00000109823	ENSMUSP00000105448
ENSMUST00000109822	ENSMUSP00000105447
ENSMUST00000125434	ENSMUSP00000123016

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004340	glucokinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005536	glucose binding
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019903	protein phosphatase binding
GO:0043531	ADP binding

Biological Process

GO:0001678	cellular glucose homeostasis
GO:0005975	carbohydrate metabolic process
GO:0005978	glycogen biosynthetic process
GO:0006003	fructose 2,6-bisphosphate metabolic process
GO:0006006	glucose metabolic process
GO:0006096	glycolytic process
GO:0006739	NADP metabolic process
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0009749	response to glucose
GO:0019932	second-messenger-mediated signaling
GO:0031018	endocrine pancreas development
GO:0032024	positive regulation of insulin secretion
GO:0032811	negative regulation of epinephrine secretion
GO:0032869	cellular response to insulin stimulus
GO:0042149	cellular response to glucose starvation
GO:0042327	positive regulation of phosphorylation
GO:0042593	glucose homeostasis
GO:0043266	regulation of potassium ion transport
GO:0044320	cellular response to leptin stimulus
GO:0045721	negative regulation of gluconeogenesis
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0045821	positive regulation of glycolytic process
GO:0046835	carbohydrate phosphorylation
GO:0050796	regulation of insulin secretion
GO:0051156	glucose 6-phosphate metabolic process
GO:0051594	detection of glucose
GO:0055088	lipid homeostasis
GO:0070509	calcium ion import

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005884	actin filament
GO:0005938	cell cortex
GO:0030141	secretory granule
GO:0045180	basal cortex