Version 5.4
Mus musculus Gene: Eif4ebp1
Summary
InnateDB Gene IDBG-145947.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif4ebp1
Gene Name eukaryotic translation initiation factor 4E binding protein 1
Synonyms 4e-bp1; AA959816; PHAS-I
Species Mus musculus
Ensembl Gene ENSMUSG00000031490
Encoded Proteins
IDBP-145949
eukaryotic translation initiation factor 4E binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25531441
Genetic deletion of Eif4ebp1 or Eif4ebp2 potentiates innate antiviral immunity by enhancing translation of Irf7.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187840:
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5\' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:27260327-27275656
Strand Forward strand
Band A2
Transcripts
ENSMUST00000033880 ENSMUSP00000033880
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008190 eukaryotic initiation factor 4E binding
GO:0030371 translation repressor activity
GO:0031369 translation initiation factor binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0002931 response to ischemia
GO:0006446 regulation of translational initiation
GO:0008286 insulin receptor signaling pathway
GO:0030324 lung development
GO:0031333 negative regulation of protein complex assembly
GO:0031929 TOR signaling
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0045931 positive regulation of mitotic cell cycle
GO:0045947 negative regulation of translational initiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000187840
View Gene Order
ENSBTAG00000027654
Not yet available
Pathways
NETPATH
REACTOME
REACT_240250
Signaling by Insulin receptor pathway
REACT_255163
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_254308
Translation pathway
REACT_247926
Metabolism of proteins pathway
REACT_241655
Release of eIF4E pathway
REACT_229570
Cap-dependent Translation Initiation pathway
REACT_262064
Eukaryotic Translation Initiation pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_240139
PI3K Cascade pathway
REACT_233572
Gene Expression pathway
REACT_243154
IRS-related events pathway
REACT_242206
IRS-mediated signalling pathway
REACT_231630
mTORC1-mediated signalling pathway
REACT_188257
Signal Transduction pathway
REACT_255725
mTOR signalling pathway
REACT_256714
PKB-mediated events pathway
KEGG
mmu04012
ErbB signaling pathway pathway
mmu04910
Insulin signaling pathway pathway
mmu05221
Acute myeloid leukemia pathway
mmu04150
mTOR signaling pathway pathway
mmu03013
RNA transport pathway
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_18
IL6 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
NetPath_24
TSLP pathway
NetPath_25
FSH pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_6836
Release of eIF4E pathway
REACT_6838
mTOR signalling pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_456
PKB-mediated events pathway
REACT_6964
mTORC1-mediated signalling pathway
REACT_1014
Translation pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_17015
Metabolism of proteins pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_71
Gene Expression pathway
REACT_206974
Insulin receptor signalling cascade pathway
REACT_213280
PKB-mediated events pathway
REACT_225366
IRS-related events triggered by IGF1R pathway
REACT_203529
Release of eIF4E pathway
REACT_216992
mTOR signalling pathway
REACT_208701
mTORC1-mediated signalling pathway
REACT_208835
IRS-related events pathway
REACT_226022
Gene Expression pathway
REACT_218564
Eukaryotic Translation Initiation pathway
REACT_225918
Cap-dependent Translation Initiation pathway
REACT_224404
IRS-mediated signalling pathway
REACT_205176
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_216354
IGF1R signaling cascade pathway
REACT_209048
Translation pathway
REACT_214353
Signal Transduction pathway
REACT_209911
PI3K Cascade pathway
REACT_219546
Signaling by Insulin receptor pathway
REACT_213782
Metabolism of proteins pathway
REACT_220444
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa05221
Acute myeloid leukemia pathway
hsa04012
ErbB signaling pathway pathway
hsa04910
Insulin signaling pathway pathway
hsa03013
RNA transport pathway
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
mtor_4pathway
mTOR signaling pathway
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
insulin_pathway
Insulin Pathway
Cross-References
SwissProt Q60876
TrEMBL
UniProt Splice Variant
Entrez Gene 13685
UniGene Mm.6700
RefSeq NM_007918
OMIM
CCDS CCDS22214
HPRD
IMGT
MGI ID MGI:103267
MGI Symbol Eif4ebp1
EMBL AK013033 AK169979 AK170031 BC002045 U28656
GenPept AAA88818 AAH02045 BAB28612 BAE41494 BAE41521
RNA Seq Atlas 13685

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca