InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ptgds

Summary

InnateDB Gene

IDBG-145983.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptgds

Gene Name

prostaglandin D2 synthase (brain)

Synonyms

21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015090

Encoded Proteins

IDBP-145985

prostaglandin D2 synthase (brain)

IDBP-252150

prostaglandin D2 synthase (brain)

IDBP-252152

prostaglandin D2 synthase (brain)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107317:
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:25466709-25470046

Strand

Reverse strand

Band

Transcripts

ENSMUST00000015234	ENSMUSP00000015234
ENSMUST00000114259	ENSMUSP00000109897
ENSMUST00000114251	ENSMUSP00000109889
ENSMUST00000144016
ENSMUST00000137417

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004667	prostaglandin-D synthase activity
GO:0005215	transporter activity
GO:0005501	retinoid binding
GO:0005504	fatty acid binding

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0006810	transport
GO:0045187	regulation of circadian sleep/wake cycle, sleep
GO:0051384	response to glucocorticoid

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0031965	nuclear membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome