InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Alg2

Summary

InnateDB Gene

IDBG-146145.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alg2

Gene Name

asparagine-linked glycosylation 2 (alpha-1,3-mannosyltransferase)

Synonyms

1110018A23Rik; 1300013N08Rik; ALPG2; CDGIi; MNCb-5081

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039740

Encoded Proteins

IDBP-146147

asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase)

IDBP-534378

asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119523:
This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:47465067-47474333

Strand

Reverse strand

Band

Transcripts

ENSMUST00000044148	ENSMUSP00000043580
ENSMUST00000136912
ENSMUST00000143104	ENSMUSP00000121934

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000033	alpha-1,3-mannosyltransferase activity
GO:0004378	GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity
GO:0005515	protein binding
GO:0033164	glycolipid 6-alpha-mannosyltransferase activity
GO:0043495	protein anchor
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0006488	dolichol-linked oligosaccharide biosynthetic process
GO:0009058	biosynthetic process
GO:0033577	protein glycosylation in endoplasmic reticulum
GO:0051592	response to calcium ion
GO:0097502	mannosylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000119523

View Gene Order

ENSBTAG00000002454

Not yet available

Pathways

NETPATH

REACTOME

REACT_262413

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway

REACT_247926

Metabolism of proteins pathway

REACT_236283

Post-translational protein modification pathway

REACT_237472

Asparagine N-linked glycosylation pathway

KEGG

mmu00510

N-Glycan biosynthesis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22433

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway

REACT_22426

Asparagine N-linked glycosylation pathway

REACT_22161

Post-translational protein modification pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa00510

N-Glycan biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.22218 Mm.482701

RefSeq

NM_019998

OMIM

CCDS

CCDS18161

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas