Version 5.4
Homo sapiens Gene: GTF2A2
Summary
InnateDB Gene IDBG-14626.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GTF2A2
Gene Name general transcription factor IIA, 2, 12kDa
Synonyms HsT18745; TF2A2; TFIIA
Species Homo sapiens
Ensembl Gene ENSG00000140307
Encoded Proteins
IDBP-238280
general transcription factor IIA, 2, 12kDa
IDBP-238282
general transcription factor IIA, 2, 12kDa
IDBP-238284
general transcription factor IIA, 2, 12kDa
IDBP-238286
general transcription factor IIA, 2, 12kDa
IDBP-480851
general transcription factor IIA, 2, 12kDa
IDBP-602159
general transcription factor IIA, 2, 12kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:59638062-59657541
Strand Reverse strand
Band q22.2
Transcripts
ENST00000267869
ENST00000396064 ENSP00000379376
ENST00000396063 ENSP00000379375
ENST00000396061 ENSP00000379373
ENST00000396060 ENSP00000379372
ENST00000484743 ENSP00000418574
ENST00000480768
ENST00000472508
ENST00000559141
ENST00000559706 ENSP00000452648
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0017025 TBP-class protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0016032 viral process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005672 transcription factor TFIIA complex
GO:0030054 cell junction
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033543
View Gene Order
ENSBTAG00000010298
Not yet available
Pathways
NETPATH
REACTOME
REACT_1655
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_22107
RNA Polymerase II Pre-transcription Events pathway
REACT_2089
RNA Polymerase II Promoter Escape pathway
REACT_1851
RNA Polymerase II Transcription Initiation pathway
REACT_834
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_6332
HIV Transcription Initiation pathway
REACT_6253
RNA Polymerase II HIV Promoter Escape pathway
REACT_6233
Transcription of the HIV genome pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
KEGG
hsa03022
Basal transcription factors pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.512934 Hs.659801
RefSeq NM_004492 XM_005254324
HUGO
OMIM
CCDS CCDS10173
HPRD 02747
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca