Version 5.4
Mus musculus Gene: Eif2a
Summary
InnateDB Gene IDBG-146374.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif2a
Gene Name eukaryotic translation initiation factor 2A
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000027810
Encoded Proteins
IDBP-146376
eukaryotic translation initiation factor 2A
IDBP-539777
eukaryotic translation initiation factor 2A
IDBP-534011
eukaryotic translation initiation factor 2A
IDBP-533040
eukaryotic translation initiation factor 2A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144895:
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002 [PubMed 12133843]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:58525821-58557501
Strand Forward strand
Band D
Transcripts
ENSMUST00000029387 ENSMUSP00000029387
ENSMUST00000137469
ENSMUST00000135876 ENSMUSP00000122375
ENSMUST00000154219 ENSMUSP00000121236
ENSMUST00000138848 ENSMUSP00000120901
ENSMUST00000138827
ENSMUST00000148251
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0043022 ribosome binding
Biological Process
GO:0006412 translation
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0006468 protein phosphorylation
GO:0009967 positive regulation of signal transduction
GO:0032933 SREBP signaling pathway
GO:0042255 ribosome assembly
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000144895
View Gene Order
ENSBTAG00000009106
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_18
IL6 pathway
REACTOME
KEGG
INOH
PID NCI
tgfbrpathway
TGF-beta receptor signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.21617 Mm.404592 Mm.471324
RefSeq NM_001005509 XM_006501321
OMIM
CCDS CCDS17367
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca