Version 5.4
Mus musculus Gene: Phpt1
Summary
InnateDB Gene IDBG-146492.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Phpt1
Gene Name phosphohistidine phosphatase 1
Synonyms 1700008C22Rik; Php14
Species Mus musculus
Ensembl Gene ENSMUSG00000036504
Encoded Proteins
IDBP-146494
phosphohistidine phosphatase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000054148:
PHPT1 is an EDTA-insensitive phosphohistidine phosphatase that catalyzes the dephosphorylation of phosphopeptide I (Ek et al., 2002 [PubMed 12383260]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:25573430-25575224
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000039156 ENSMUSP00000037417
ENSMUST00000147096
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0008969 phosphohistidine phosphatase activity
GO:0019855 calcium channel inhibitor activity
GO:0044325 ion channel binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035971 peptidyl-histidine dephosphorylation
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0051350 negative regulation of lyase activity
GO:2000147 positive regulation of cell motility
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2000984 negative regulation of ATP citrate synthase activity
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000054148
View Gene Order
ENSBTAG00000021549
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00051
Fructose and mannose metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa00051
Fructose and mannose metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_029293
OMIM
CCDS CCDS15781
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca