Version 5.4
Homo sapiens Gene: STON2
Summary
InnateDB Gene IDBG-14658.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STON2
Gene Name stonin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140022
Encoded Proteins
IDBP-14660
stonin 2
IDBP-600367
stonin 2
IDBP-597058
stonin 2
IDBP-597324
stonin 2
IDBP-599764
stonin 2
IDBP-809504
stonin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. The encoded protein has also been shown to participate in synaptic vesicle recycling through interaction with synaptotagmin 1 required for neurotransmission. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:81260656-81436465
Strand Reverse strand
Band q31.1
Transcripts
ENST00000267540 ENSP00000267540
ENST00000555447 ENSP00000450857
ENST00000553821 ENSP00000450577
ENST00000555284
ENST00000556280
ENST00000555226
ENST00000557055 ENSP00000450990
ENST00000554710 ENSP00000451383
ENST00000614646 ENSP00000477736
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0016192 vesicle-mediated transport
GO:0030100 regulation of endocytosis
GO:0048488 synaptic vesicle endocytosis
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0008021 synaptic vesicle
GO:0030054 cell junction
GO:0030131 clathrin adaptor complex
GO:0030136 clathrin-coated vesicle
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020961
View Gene Order
ENSBTAG00000025308
Not yet available
Cross-References
SwissProt Q8WXE9
TrEMBL G3V322
UniProt Splice Variant
Entrez Gene 85439
UniGene Hs.14248 Hs.622960
RefSeq NM_001256430 NM_033104 XM_006720279 XM_006720280 XM_006720281
HUGO HGNC:30652
OMIM 608467
CCDS CCDS58332 CCDS9875
HPRD
IMGT
EMBL AB208948 AF255309 AF380833 AF449430 AL121769 AL136040 BC069389 BC117493
GenPept AAH69389 AAI17494 AAK57558 AAK76362 AAL47008 BAD92185
RNA Seq Atlas 85439

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca