InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lox

Summary

InnateDB Gene

IDBG-146632.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lox

Gene Name

lysyl oxidase

Synonyms

AI893619; rrg; TSC-160

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024529

Encoded Proteins

IDBP-146634

lysyl oxidase

IDBP-622685

lysyl oxidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a precursor protein that belongs to the lysyl oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active enzyme plays a role in cross-linking of collagen and elastin and is essential for development of cardiovascular and respiratory systems, and development of skin and connective tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:52516069-52529867

Strand

Reverse strand

Band

Transcripts

ENSMUST00000025409	ENSMUSP00000025409
ENSMUST00000171470	ENSMUSP00000129247

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004720	protein-lysine 6-oxidase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

Biological Process

GO:0001568	blood vessel development
GO:0009725	response to hormone
GO:0030199	collagen fibril organization
GO:0030324	lung development
GO:0042060	wound healing
GO:0042493	response to drug
GO:0048251	elastic fiber assembly
GO:0048545	response to steroid hormone
GO:0055114	oxidation-reduction process