InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ms4a2

Summary

InnateDB Gene

IDBG-146783.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ms4a2

Gene Name

membrane-spanning 4-domains, subfamily A, member 2

Synonyms

Fce1b; Fcer1b; fcERI; FcRB; Fcrbeta; Ms4a1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024680

Encoded Proteins

IDBP-146785

membrane-spanning 4-domains, subfamily A, member 2

IDBP-619946

membrane-spanning 4-domains, subfamily A, member 2

IDBP-788390

membrane-spanning 4-domains, subfamily A, member 2

IDBP-788393

membrane-spanning 4-domains, subfamily A, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the membrane-spanning 4A family. The encoded protein is the beta subunit of the high affinity IgE receptor and is localized to the membrane. The encoded protein is required for full activation of mast cells, including the release of histamine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:11615523-11623719

Strand

Reverse strand

Band

Transcripts

ENSMUST00000025583	ENSMUSP00000025583
ENSMUST00000164792	ENSMUSP00000127373
ENSMUST00000186978	ENSMUSP00000140628
ENSMUST00000189641	ENSMUSP00000139841
ENSMUST00000186413

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	8 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019767	IgE receptor activity
GO:0019863	IgE binding
GO:0019901	protein kinase binding
GO:0042169	SH2 domain binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043306	positive regulation of mast cell degranulation
GO:0050663	cytokine secretion
GO:0051279	regulation of release of sequestered calcium ion into cytosol

Cellular Component

GO:0005768	endosome
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0032998	Fc-epsilon receptor I complex
GO:0045121	membrane raft