Version 5.4
Mus musculus Gene: Slc9a6
Summary
InnateDB Gene IDBG-146858.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc9a6
Gene Name solute carrier family 9 (sodium/hydrogen exchanger), member 6
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000060681
Encoded Proteins
IDBP-146860
solute carrier family 9 (sodium/hydrogen exchanger), member 6
IDBP-251043
solute carrier family 9 (sodium/hydrogen exchanger), member 6
IDBP-531738
solute carrier family 9 (sodium/hydrogen exchanger), member 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198689:
This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic mental retardation, Christianson type. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:56609757-56664230
Strand Forward strand
Band A6
Transcripts
ENSMUST00000077741 ENSMUSP00000076922
ENSMUST00000114784 ENSMUSP00000110432
ENSMUST00000144068 ENSMUSP00000115364
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0015299 solute:proton antiporter activity
GO:0015385 sodium:proton antiporter activity
Biological Process
GO:0006812 cation transport
GO:0006814 sodium ion transport
GO:0006885 regulation of pH
GO:0015992 proton transport
GO:0031547 brain-derived neurotrophic factor receptor signaling pathway
GO:0035725 sodium ion transmembrane transport
GO:0048675 axon extension
GO:0048812 neuron projection morphogenesis
GO:0050808 synapse organization
GO:0051386 regulation of neurotrophin TRK receptor signaling pathway
GO:0055085 transmembrane transport
GO:0060996 dendritic spine development
GO:0097484 dendrite extension
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0043679 axon terminus
GO:0044308 axonal spine
GO:0045202 synapse
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198689
View Gene Order
ENSBTAG00000009523
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04260
Cardiac muscle contraction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19314
Sodium/Proton exchangers pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
hsa04260
Cardiac muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B0QZV3
UniProt Splice Variant
Entrez Gene 236794
UniGene Mm.17815
RefSeq NM_172780 XM_006527979 XM_006527980
OMIM
CCDS CCDS40979
HPRD
IMGT
MGI ID MGI:2443511
MGI Symbol Slc9a6
EMBL AC048362 AL672085
GenPept
RNA Seq Atlas 236794

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca