InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Baat

Summary

InnateDB Gene

IDBG-146969.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Baat

Gene Name

bile acid-Coenzyme A: amino acid N-acyltransferase

Synonyms

AI118337; AI158864; BAT

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039653

Encoded Proteins

IDBP-146971

bile acid-Coenzyme A: amino acid N-acyltransferase

IDBP-624310

bile acid-Coenzyme A: amino acid N-acyltransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136881:
The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:49489422-49506557

Strand

Reverse strand

Band

Transcripts

ENSMUST00000043056	ENSMUSP00000041983
ENSMUST00000166036	ENSMUSP00000129603

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0016290	palmitoyl-CoA hydrolase activity
GO:0016410	N-acyltransferase activity
GO:0016787	hydrolase activity
GO:0016790	thiolester hydrolase activity
GO:0047963	glycine N-choloyltransferase activity
GO:0052815	medium-chain acyl-CoA hydrolase activity
GO:0052816	long-chain acyl-CoA hydrolase activity
GO:0052817	very long chain acyl-CoA hydrolase activity

Biological Process

GO:0001889	liver development
GO:0002152	bile acid conjugation
GO:0006544	glycine metabolic process
GO:0006631	fatty acid metabolic process
GO:0006637	acyl-CoA metabolic process
GO:0006699	bile acid biosynthetic process
GO:0008206	bile acid metabolic process
GO:0019530	taurine metabolic process
GO:0031100	organ regeneration