InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Wrn

Summary

InnateDB Gene

IDBG-147033.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wrn

Gene Name

Werner syndrome homolog (human)

Synonyms

AI846146

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031583

Encoded Proteins

IDBP-147035

Werner syndrome homolog (human)

IDBP-147037

Werner syndrome homolog (human)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165392:
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3\' to 5\' DNA helicase activity, and is also a 3\' to 5\' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:33234384-33385527

Strand

Reverse strand

Band

Transcripts

ENSMUST00000033990	ENSMUSP00000033990
ENSMUST00000033991	ENSMUSP00000033991

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0000403	Y-form DNA binding
GO:0000405	bubble DNA binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003824	catalytic activity
GO:0004003	ATP-dependent DNA helicase activity
GO:0004386	helicase activity
GO:0004527	exonuclease activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0008408	3'-5' exonuclease activity
GO:0009378	four-way junction helicase activity
GO:0016887	ATPase activity
GO:0030145	manganese ion binding
GO:0032403	protein complex binding
GO:0042803	protein homodimerization activity
GO:0043138	3'-5' DNA helicase activity
GO:0043140	ATP-dependent 3'-5' DNA helicase activity
GO:0051880	G-quadruplex DNA binding

Biological Process

GO:0000723	telomere maintenance
GO:0000731	DNA synthesis involved in DNA repair
GO:0001302	replicative cell aging
GO:0006139	nucleobase-containing compound metabolic process
GO:0006200	ATP catabolic process
GO:0006259	DNA metabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006302	double-strand break repair
GO:0006310	DNA recombination
GO:0006974	cellular response to DNA damage stimulus
GO:0006979	response to oxidative stress
GO:0007569	cell aging
GO:0009267	cellular response to starvation
GO:0010225	response to UV-C
GO:0010259	multicellular organismal aging
GO:0031297	replication fork processing
GO:0032066	nucleolus to nucleoplasm transport
GO:0032508	DNA duplex unwinding
GO:0040009	regulation of growth rate
GO:0042981	regulation of apoptotic process
GO:0044237	cellular metabolic process
GO:0051345	positive regulation of hydrolase activity
GO:0071480	cellular response to gamma radiation
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005813	centrosome
GO:0032389	MutLalpha complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000165392

View Gene Order

ENSBTAG00000021592

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

telomerasepathway

Regulation of Telomerase

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.422146

RefSeq

NM_001122822 NM_011721 XM_006509091 XM_006509092 XM_006509093

OMIM

CCDS

CCDS22229

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas