InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aldob

Summary

InnateDB Gene

IDBG-147038.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aldob

Gene Name

aldolase B, fructose-bisphosphate

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028307

Encoded Proteins

IDBP-147040

aldolase B, fructose-bisphosphate

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136872:
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related \'housekeeping\' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5%% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:49535995-49549546

Strand

Reverse strand

Band

Transcripts

ENSMUST00000029987	ENSMUSP00000029987
ENSMUST00000148415
ENSMUST00000144372

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004332	fructose-bisphosphate aldolase activity
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0042802	identical protein binding
GO:0051117	ATPase binding
GO:0070061	fructose binding

Biological Process

GO:0006000	fructose metabolic process
GO:0006096	glycolytic process
GO:0006116	NADH oxidation
GO:0030388	fructose 1,6-bisphosphate metabolic process
GO:0032781	positive regulation of ATPase activity
GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly

Cellular Component

GO:0005815	microtubule organizing center
GO:0034451	centriolar satellite
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000136872

View Gene Order

ENSBTAG00000015358

Not yet available

Pathways

NETPATH

REACTOME

REACT_189085

Disease pathway

REACT_232322

Glycolysis pathway

REACT_261601

Glucose metabolism pathway

REACT_188937

Metabolism pathway

REACT_230419

Fructose catabolism pathway

REACT_263230

Gluconeogenesis pathway

REACT_203949

Glycogen storage diseases pathway

REACT_203841

Myoclonic epilepsy of Lafora pathway

REACT_248571

Metabolism of carbohydrates pathway

KEGG

mmu00030

Pentose phosphate pathway pathway

mmu00051

Fructose and mannose metabolism pathway

mmu00010

Glycolysis / Gluconeogenesis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_1571

Fructose catabolism pathway

REACT_1383

Glycolysis pathway

REACT_1520

Gluconeogenesis pathway

REACT_200783

Myoclonic epilepsy of Lafora pathway

REACT_474

Metabolism of carbohydrates pathway

REACT_111217

Metabolism pathway

REACT_116125

Disease pathway

REACT_723

Glucose metabolism pathway

REACT_200833

Glycogen storage diseases pathway

KEGG

hsa00010

Glycolysis / Gluconeogenesis pathway

hsa00030

Pentose phosphate pathway pathway

hsa00051

Fructose and mannose metabolism pathway

INOH

INOH website

Glycolysis Gluconeogenesis pathway

INOH website

Fructose Mannose metabolism pathway

INOH website

Pentose phosphate cycle pathway

PID NCI

hnf3bpathway

FOXA2 and FOXA3 transcription factor networks

Cross-References

SwissProt

Q91Y97

TrEMBL

Q3UER1

UniProt Splice Variant

Entrez Gene

230163

UniGene

Mm.218862 Mm.482116 Mm.486174

RefSeq

NM_144903

OMIM

CCDS

CCDS18176

HPRD

IMGT

MGI ID

MGI:87995

MGI Symbol

Aldob

EMBL

AF403565 AF403566 AF403567 AK135385 AK149395 AK149598 AK167334 AK168600 AK168997 BC016435 BC022113 BC024056 BC024112 BC026577 BC030724 BC030725 BC034169 BC034171 BC034172 BC034173 BC036130 BC036131 BC036132 BC036133 CH466565

GenPept

AAH16435 AAH22113 AAH24056 AAH24112 AAH26577 AAH30724 AAH30725 AAH34169 AAH34171 AAH34172 AAH34173 AAH36130 AAH36131 AAH36132 AAH36133 AAL06323 BAE22514 BAE28850 BAE28983 BAE39436 BAE40467 BAE40796 EDL02311

RNA Seq Atlas

230163