Version 5.4
Homo sapiens Gene: ANXA2
Summary
InnateDB Gene IDBG-14711.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANXA2
Gene Name annexin A2
Synonyms ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2; LPC2D; P36; PAP-IV
Species Homo sapiens
Ensembl Gene ENSG00000182718
Encoded Proteins
IDBP-14715
annexin A2
IDBP-238304
annexin A2
IDBP-374227
annexin A2
IDBP-374228
annexin A2
IDBP-591982
annexin A2
IDBP-593241
annexin A2
IDBP-589694
annexin A2
IDBP-593208
annexin A2
IDBP-591634
annexin A2
IDBP-592872
annexin A2
IDBP-590830
annexin A2
IDBP-586383
annexin A2
IDBP-596568
annexin A2
IDBP-596032
annexin A2
IDBP-597550
annexin A2
IDBP-595540
annexin A2
IDBP-599067
annexin A2
IDBP-593359
annexin A2
IDBP-593470
annexin A2
IDBP-597653
annexin A2
IDBP-597737
annexin A2
IDBP-591515
annexin A2
IDBP-587620
annexin A2
IDBP-588495
annexin A2
IDBP-591705
annexin A2
IDBP-596037
annexin A2
IDBP-588577
annexin A2
IDBP-584541
annexin A2
IDBP-595990
annexin A2
IDBP-593238
annexin A2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19965653
ANXA2 is found in a heterotetrameric complex with S100A10, serving as a key extracellular binding partner for pathogens and host proteins alike and can also can be shed or secreted. ANXA2 tetramer can activate human and murine macrophages through TLR4 demonstrating an important role for ANXA2 in the detection of danger to the host, whether from injury or invasion.
PMID 21115493
ANXA2 :: S100A10 is a key profibrinolytic complex that assembles plasminogen and tissue plasminogen activator, and promotes plasmin generation. As a negative feedback regulation, plasmin can induce serine phosphorylation of ANXA2 and prevents the translocation to cell surface.
InnateDB Annotation from Orthologs
Summary
PMID 21115493
[Mus musculus] Anxa2 :: S100a10 is a key profibrinolytic complex that assembles plasminogen and tissue plasminogen activator, and promotes plasmin generation. As a negative feedback regulation, plasmin can induce serine phosphorylation of Anxa2 and prevents the translocation to cell surface.
Entrez Gene
Summary This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:60347134-60402883
Strand Reverse strand
Band q22.2
Transcripts
ENST00000332680 ENSP00000346032
ENST00000396024 ENSP00000379342
ENST00000421017 ENSP00000411352
ENST00000451270 ENSP00000387545
ENST00000504475
ENST00000560014 ENSP00000453754
ENST00000559647
ENST00000559176 ENSP00000453464
ENST00000558985 ENSP00000453039
ENST00000560466 ENSP00000453841
ENST00000559818 ENSP00000453859
ENST00000558132 ENSP00000454096
ENST00000561022 ENSP00000452876
ENST00000560367 ENSP00000453556
ENST00000558503 ENSP00000453356
ENST00000558998 ENSP00000453925
ENST00000559559
ENST00000560389 ENSP00000453579
ENST00000560165 ENSP00000452921
ENST00000559113 ENSP00000453869
ENST00000557906 ENSP00000452895
ENST00000559725 ENSP00000453174
ENST00000559350 ENSP00000453663
ENST00000558558 ENSP00000452981
ENST00000558986 ENSP00000453739
ENST00000559467 ENSP00000453000
ENST00000559956 ENSP00000453694
ENST00000559780 ENSP00000453770
ENST00000560468 ENSP00000452858
ENST00000561445
ENST00000557937
ENST00000557904 ENSP00000452958
ENST00000559370 ENSP00000453566
ENST00000558169 ENSP00000453945
ENST00000560546
ENST00000557986 ENSP00000453742
ENST00000560936
ENST00000560495
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 89 [view]
Protein-Protein 89 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0008092 cytoskeletal protein binding
GO:0017137 Rab GTPase binding
GO:0019834 phospholipase A2 inhibitor activity
GO:0044548 S100 protein binding
GO:0044822 poly(A) RNA binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0001525 angiogenesis
GO:0001765 membrane raft assembly
GO:0001934 positive regulation of protein phosphorylation
GO:0006900 membrane budding
GO:0007589 body fluid secretion
GO:0030199 collagen fibril organization
GO:0031340 positive regulation of vesicle fusion
GO:0036035 osteoclast development
GO:0042730 fibrinolysis
GO:0043086 negative regulation of catalytic activity
GO:0045087 innate immune response (InnateDB)
GO:0048146 positive regulation of fibroblast proliferation
GO:0051099 positive regulation of binding
GO:0051290 protein heterotetramerization
GO:0071229 cellular response to acid
GO:0072661 protein targeting to plasma membrane
Cellular Component
GO:0001726 ruffle
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005811 lipid particle
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0009986 cell surface
GO:0016020 membrane
GO:0019897 extrinsic component of plasma membrane
GO:0030496 midbody
GO:0031012 extracellular matrix
GO:0031902 late endosome membrane
GO:0031982 vesicle
GO:0035749 myelin sheath adaxonal region
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0043220 Schmidt-Lanterman incisure
GO:0043234 protein complex
GO:0044354 macropinosome
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032231
View Gene Order
ENSBTAG00000009615
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
REACT_641
Dissolution of Fibrin Clot pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_267716
Orphan transporters pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.511605 Hs.546235 Hs.591361 Hs.743634
RefSeq NM_001002857 NM_001002858 NM_001136015 NM_004039
HUGO
OMIM
CCDS CCDS10175 CCDS32256
HPRD 01061
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca