InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rnf20

Summary

InnateDB Gene

IDBG-147129.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf20

Gene Name

ring finger protein 20

Synonyms

4833430L21Rik; AW540162; C79397; mKIAA4116

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028309

Encoded Proteins

IDBP-147133

ring finger protein 20

IDBP-539305

ring finger protein 20

IDBP-536137

ring finger protein 20

IDBP-540635

ring finger protein 20

IDBP-624330

ring finger protein 20

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155827:
The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:49632006-49656887

Strand

Forward strand

Band

Transcripts

ENSMUST00000029989	ENSMUSP00000029989
ENSMUST00000140341	ENSMUSP00000121334
ENSMUST00000156314	ENSMUSP00000118293
ENSMUST00000146547	ENSMUSP00000120668
ENSMUST00000132782
ENSMUST00000126675
ENSMUST00000149862
ENSMUST00000131962
ENSMUST00000138490
ENSMUST00000167496	ENSMUSP00000128546

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0042393	histone binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006355	regulation of transcription, DNA-templated
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007165	signal transduction
GO:0010390	histone monoubiquitination
GO:0016574	histone ubiquitination
GO:0030336	negative regulation of cell migration
GO:0031062	positive regulation of histone methylation
GO:0033523	histone H2B ubiquitination
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0033503	HULC complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000155827

View Gene Order

ENSBTAG00000009516

Not yet available

Cross-References

SwissProt

TrEMBL

A2AIR0

UniProt Splice Variant

Entrez Gene

109331

UniGene

Mm.24765 Mm.472902

RefSeq

NM_001163263 NM_182999 XM_006537553

OMIM

CCDS

CCDS18178

HPRD

IMGT

MGI ID

MGI:1925927

MGI Symbol

Rnf20

EMBL

AL732521

GenPept

RNA Seq Atlas

109331