Version 5.4
Homo sapiens Gene: TXNRD2
Summary
InnateDB Gene IDBG-1472.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TXNRD2
Gene Name thioredoxin reductase 2
Synonyms SELZ; TR; TR-BETA; TR3; TRXR2
Species Homo sapiens
Ensembl Gene ENSG00000184470
Encoded Proteins
IDBP-1478
thioredoxin reductase 2
IDBP-228024
thioredoxin reductase 2
IDBP-228026
thioredoxin reductase 2
IDBP-228028
thioredoxin reductase 2
IDBP-228030
thioredoxin reductase 2
IDBP-809302
thioredoxin reductase 2
IDBP-809307
thioredoxin reductase 2
IDBP-809314
thioredoxin reductase 2
IDBP-809316
thioredoxin reductase 2
IDBP-809317
thioredoxin reductase 2
IDBP-809320
thioredoxin reductase 2
IDBP-809305
thioredoxin reductase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22. [provided by RefSeq, Jul 2008]
This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:19875517-19941992
Strand Reverse strand
Band q11.21
Transcripts
ENST00000334363 ENSP00000334451
ENST00000400525 ENSP00000383369
ENST00000400521 ENSP00000383365
ENST00000400519 ENSP00000383363
ENST00000400518 ENSP00000383362
ENST00000494454
ENST00000474308 ENSP00000485665
ENST00000487165
ENST00000462330 ENSP00000485603
ENST00000495655
ENST00000485358 ENSP00000485499
ENST00000462843 ENSP00000485466
ENST00000491939 ENSP00000485543
ENST00000475995 ENSP00000485290
ENST00000484672
ENST00000471835
ENST00000496729
ENST00000542719 ENSP00000485128
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004791 thioredoxin-disulfide reductase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0000305 response to oxygen radical
GO:0007507 heart development
GO:0008033 tRNA processing
GO:0030097 hemopoiesis
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000075704
View Gene Order
ENSBTAG00000043581
Not yet available
Pathways
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_172715
Detoxification of Reactive Oxygen Species pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00450
Selenocompound metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q9NNW7
TrEMBL D3YTF8 E7EWK1 F5H1L4 F5H2V0
UniProt Splice Variant
Entrez Gene 10587
UniGene Hs.626297
RefSeq NM_001282512 NM_006440
HUGO HGNC:18155
OMIM 606448
CCDS CCDS42981 CCDS63402
HPRD
IMGT
EMBL AB019694 AB019695 AC000078 AC000080 AC000090 AF044212 AF106697 AF166126 AF166127 AF171054 AF201385 BC007489
GenPept AAD19597 AAD25167 AAD51324 AAF21431 AAF21432 AAG47635 AAH07489 BAA77601 BAA77602
RNA Seq Atlas 10587

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca