Version 5.4
Homo sapiens Gene: LMCD1
Summary
InnateDB Gene IDBG-14742.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LMCD1
Gene Name LIM and cysteine-rich domains 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000071282
Encoded Proteins
IDBP-14744
LIM and cysteine-rich domains 1
IDBP-235507
LIM and cysteine-rich domains 1
IDBP-361116
LIM and cysteine-rich domains 1
IDBP-361118
LIM and cysteine-rich domains 1
IDBP-361119
LIM and cysteine-rich domains 1
IDBP-361120
LIM and cysteine-rich domains 1
IDBP-599070
LIM and cysteine-rich domains 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site. The presence of LIM domains implies involvement in protein-protein interactions. Expression of this gene has been detected in most tissues, with highest expression in skeletal muscle. Transcript variants utilizing alternative polyA signals have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:8501707-8568125
Strand Forward strand
Band p25.3
Transcripts
ENST00000157600 ENSP00000157600
ENST00000397386 ENSP00000380542
ENST00000415597 ENSP00000400555
ENST00000454244 ENSP00000396515
ENST00000456506 ENSP00000405049
ENST00000426878 ENSP00000411222
ENST00000470776
ENST00000535732 ENSP00000441100
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0010611 regulation of cardiac muscle hypertrophy
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057604
View Gene Order
ENSBTAG00000005431
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001278233 NM_001278234 NM_001278235 NM_014583
HUGO
OMIM
CCDS CCDS33688 CCDS63533 CCDS63534
HPRD 06891
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca