Version 5.4
Mus musculus Gene: Jarid2
Summary
InnateDB Gene IDBG-147776.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Jarid2
Gene Name jumonji, AT rich interactive domain 2
Synonyms Jmj; jumonji
Species Mus musculus
Ensembl Gene ENSMUSG00000038518
Encoded Proteins
IDBP-147778
jumonji, AT rich interactive domain 2
IDBP-620353
jumonji, AT rich interactive domain 2
IDBP-620354
jumonji, AT rich interactive domain 2
IDBP-620356
jumonji, AT rich interactive domain 2
IDBP-620357
jumonji, AT rich interactive domain 2
IDBP-620358
jumonji, AT rich interactive domain 2
IDBP-620359
jumonji, AT rich interactive domain 2
IDBP-620361
jumonji, AT rich interactive domain 2
IDBP-620362
jumonji, AT rich interactive domain 2
IDBP-620363
jumonji, AT rich interactive domain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000008083:
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:44729474-44921643
Strand Forward strand
Band A5
Transcripts
ENSMUST00000044608 ENSMUSP00000037774
ENSMUST00000174394
ENSMUST00000174068 ENSMUSP00000134593
ENSMUST00000172830 ENSMUSP00000133653
ENSMUST00000173704 ENSMUSP00000134675
ENSMUST00000173367 ENSMUSP00000134658
ENSMUST00000172708
ENSMUST00000173246 ENSMUSP00000134205
ENSMUST00000174086 ENSMUSP00000133812
ENSMUST00000174557
ENSMUST00000174683
ENSMUST00000172977 ENSMUSP00000134276
ENSMUST00000172924
ENSMUST00000172581
ENSMUST00000173906 ENSMUSP00000134630
ENSMUST00000173003 ENSMUSP00000134302
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 34 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001889 liver development
GO:0006351 transcription, DNA-templated
GO:0008285 negative regulation of cell proliferation
GO:0016568 chromatin modification
GO:0031061 negative regulation of histone methylation
GO:0042127 regulation of cell proliferation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048863 stem cell differentiation
GO:0051574 positive regulation of histone H3-K9 methylation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0035097 histone methyltransferase complex
GO:0035098 ESC/E(Z) complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000008083
View Gene Order
ENSBTAG00000012938
Not yet available
Pathways
NETPATH
REACTOME
REACT_222475
PRC2 methylates histones and DNA pathway
REACT_205737
Epigenetic regulation of gene expression pathway
REACT_233572
Gene Expression pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_200808
PRC2 methylates histones and DNA pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q62315
TrEMBL G3UXE0 G3UXT1 G3UZQ8
UniProt Splice Variant
Entrez Gene 16468
UniGene Mm.25059 Mm.470471 Mm.488682
RefSeq NM_021878 NM_001205043 NM_001205044 XM_006516855 XM_006516856 XM_006516857 XM_006516858 XM_006516859 XM_006516860
OMIM
CCDS CCDS36646
HPRD
IMGT
MGI ID MGI:104813
MGI Symbol Jarid2
EMBL AC166074 AC170597 AK045214 AK147226 AK164134 BC003374 BC052444 BC060695 CH466546 D31967
GenPept AAH03374 AAH52444 AAH60695 BAA06736 BAC32264 BAE27780 BAE37641 EDL41007
RNA Seq Atlas 16468

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca