Version 5.4
Mus musculus Gene: Hoxa5
Summary
InnateDB Gene IDBG-147940.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hoxa5
Gene Name homeobox A5
Synonyms Hox-1.3
Species Mus musculus
Ensembl Gene ENSMUSG00000038253
Encoded Proteins
IDBP-147942
homeobox A5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106004:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:52201754-52204587
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000048794 ENSMUSP00000039012
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001501 skeletal system development
GO:0002009 morphogenesis of an epithelium
GO:0003016 respiratory system process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007389 pattern specification process
GO:0007585 respiratory gaseous exchange
GO:0009952 anterior/posterior pattern specification
GO:0010870 positive regulation of receptor biosynthetic process
GO:0016477 cell migration
GO:0016525 negative regulation of angiogenesis
GO:0030324 lung development
GO:0030878 thyroid gland development
GO:0033599 regulation of mammary gland epithelial cell proliferation
GO:0035264 multicellular organism growth
GO:0043065 positive regulation of apoptotic process
GO:0045639 positive regulation of myeloid cell differentiation
GO:0045647 negative regulation of erythrocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048286 lung alveolus development
GO:0048704 embryonic skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0060435 bronchiole development
GO:0060439 trachea morphogenesis
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060480 lung goblet cell differentiation
GO:0060481 lobar bronchus epithelium development
GO:0060484 lung-associated mesenchyme development
GO:0060535 trachea cartilage morphogenesis
GO:0060536 cartilage morphogenesis
GO:0060574 intestinal epithelial cell maturation
GO:0060638 mesenchymal-epithelial cell signaling
GO:0060644 mammary gland epithelial cell differentiation
GO:0060749 mammary gland alveolus development
GO:0060764 cell-cell signaling involved in mammary gland development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000106004
View Gene Order
ENSBTAG00000012211
Not yet available
Cross-References
SwissProt P09021
TrEMBL Q3UNA0
UniProt Splice Variant
Entrez Gene 15402
UniGene Mm.173
RefSeq NM_010453
OMIM
CCDS CCDS20143
HPRD
IMGT
MGI ID MGI:96177
MGI Symbol Hoxa5
EMBL AK144356 BC011063 M28021 M36604 X16840 Y00208
GenPept AAA37837 AAA37838 AAH11063 BAE25847 CAA34738 CAA68364
RNA Seq Atlas 15402

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca