InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mme

Summary

InnateDB Gene

IDBG-147991.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mme

Gene Name

membrane metallo endopeptidase

Synonyms

6030454K05Rik; C85356; CALLA; CD10; NEP; SFE

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027820

Encoded Proteins

IDBP-147993

membrane metallo endopeptidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196549:
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85%% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5\' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:63295872-63382231

Strand

Forward strand

Band

Transcripts

ENSMUST00000029400

ENSMUSP00000029400

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008270	zinc ion binding
GO:0042277	peptide binding

Biological Process

GO:0001822	kidney development
GO:0006508	proteolysis
GO:0006518	peptide metabolic process
GO:0019233	sensory perception of pain
GO:0046449	creatinine metabolic process
GO:0050435	beta-amyloid metabolic process
GO:0071345	cellular response to cytokine stimulus
GO:0071492	cellular response to UV-A
GO:0071493	cellular response to UV-B
GO:0090399	replicative senescence

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005903	brush border
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0044306	neuron projection terminus
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000196549

View Gene Order

ENSBTAG00000002075

Not yet available

Pathways

NETPATH

REACTOME

REACT_247926

Metabolism of proteins pathway

REACT_206913

Peptide hormone metabolism pathway

REACT_196539

Metabolism of Angiotensinogen to Angiotensins pathway

KEGG

mmu04614

Renin-angiotensin system pathway

mmu05010

Alzheimer's disease pathway

mmu04640

Hematopoietic cell lineage pathway

mmu04974

Protein digestion and absorption pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_147707

Metabolism of Angiotensinogen to Angiotensins pathway

REACT_17015

Metabolism of proteins pathway

REACT_160078

Peptide hormone metabolism pathway

KEGG

hsa04614

Renin-angiotensin system pathway

hsa04640

Hematopoietic cell lineage pathway

hsa05010

Alzheimer's disease pathway

hsa04974

Protein digestion and absorption pathway

INOH

PID NCI

Cross-References

SwissProt

Q61391

TrEMBL

Q8BNU9

UniProt Splice Variant

Entrez Gene

17380

UniGene

Mm.296022 Mm.422356

RefSeq

NM_001289462 NM_001289463 NM_008604 XM_006501095 XM_006501096 XM_006501097 XM_006501098 XM_006501099

OMIM

CCDS

CCDS17381

HPRD

IMGT

MGI ID

MGI:97004

MGI Symbol

Mme

EMBL

AK031446 AK033824 AK080202 BC034092 BC066840 M81591

GenPept

AAA37386 AAH34092 AAH66840 BAC27410 BAC28487 BAC37847

RNA Seq Atlas

17380