Version 5.4
Mus musculus Gene: Il1r2
Summary
InnateDB Gene IDBG-148186.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il1r2
Gene Name interleukin 1 receptor, type II
Synonyms CD121b; Il1r-2
Species Mus musculus
Ensembl Gene ENSMUSG00000026073
Encoded Proteins
IDBP-148188
interleukin 1 receptor, type II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25461404
Adam17 affects sensitivity to interleukin-1 by changing the balance between Il1r1 and Il1r2 receptors.
InnateDB Annotation from Orthologs
Summary
PMID 23395675
[Homo sapiens] IL1R2 binds to IL1A to limit post-necrotic inflammation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115590:
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:40084768-40125219
Strand Forward strand
Band B
Transcripts
ENSMUST00000027243 ENSMUSP00000027243
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004910 interleukin-1, Type II, blocking receptor activity
GO:0005515 protein binding
Biological Process
GO:0019221 cytokine-mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115590
View Gene Order
ENSBTAG00000006343
Not yet available
Pathways
NETPATH
REACTOME
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_261687
Signaling by Interleukins pathway
REACT_224208
Interleukin-1 signaling pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04640
Hematopoietic cell lineage pathway
mmu04010
MAPK signaling pathway pathway
mmu05146
Amoebiasis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_13
IL1 pathway
REACTOME
REACT_22442
Interleukin-1 signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04010
MAPK signaling pathway pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa05146
Amoebiasis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
il1pathway
IL1-mediated signaling events
Cross-References
SwissProt P27931
TrEMBL Q4FK69
UniProt Splice Variant
Entrez Gene 16178
UniGene Mm.1349
RefSeq NM_010555 XM_006495724 XM_006495725
OMIM
CCDS CCDS14909
HPRD
IMGT
MGI ID MGI:96546
MGI Symbol Il1r2
EMBL AK132264 CH466536 CT010182 X59769
GenPept BAE21067 CAA42440 CAJ18390 EDL14571
RNA Seq Atlas 16178

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca