InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nthl1

Summary

InnateDB Gene

IDBG-148269.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nthl1

Gene Name

nth (endonuclease III)-like 1 (E.coli)

Synonyms

Nth1; Octs3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041429

Encoded Proteins

IDBP-148271

nth (endonuclease III)-like 1 (E.coli)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065057:
The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:24632682-24638838

Strand

Forward strand

Band

A3.3

Transcripts

ENSMUST00000047611

ENSMUSP00000047413

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003824	catalytic activity
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
GO:0005515	protein binding
GO:0019104	DNA N-glycosylase activity
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006285	base-excision repair, AP site formation
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion