InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dgkg

Summary

InnateDB Gene

IDBG-148272.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dgkg

Gene Name

diacylglycerol kinase, gamma

Synonyms

2900055E17Rik; 90kDa; AI854428; Dagk3; E430001K23Rik; mKIAA4131

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022861

Encoded Proteins

IDBP-148274

diacylglycerol kinase, gamma

IDBP-148276

diacylglycerol kinase, gamma

IDBP-539232

diacylglycerol kinase, gamma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000058866:
This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:22468461-22657221

Strand

Reverse strand

Band

Transcripts

ENSMUST00000089925	ENSMUSP00000087371
ENSMUST00000023578	ENSMUSP00000023578
ENSMUST00000137311	ENSMUSP00000114441
ENSMUST00000150553

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005509	calcium ion binding
GO:0005524	ATP binding

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0016310	phosphorylation
GO:0035556	intracellular signal transduction
GO:0048666	neuron development