Version 5.4
Mus musculus Gene: Il1rl1
Summary
InnateDB Gene IDBG-148423.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il1rl1
Gene Name interleukin 1 receptor-like 1
Synonyms DER4; Fit-1; Ly84; St2; St2-rs1; ST2L; T1; T1/ST2
Species Mus musculus
Ensembl Gene ENSMUSG00000026069
Encoded Proteins
IDBP-148425
interleukin 1 receptor-like 1
IDBP-148427
interleukin 1 receptor-like 1
IDBP-625869
interleukin 1 receptor-like 1
IDBP-625870
interleukin 1 receptor-like 1
IDBP-625872
interleukin 1 receptor-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22922442
IL1RL1 (ST2) pre-treatment suppresses cytokine production and inhibits LPS signalling in dendritic cells. (Demonstrated in human)
PMID 25786179
Cigarette smoke decreases Il1rl1 expression on group 2 innate lymphoid cells while elevating Il1rl1 expression on macrophages and natural killer cells, thus altering Il33 responsiveness within the lung to infection.
InnateDB Annotation from Orthologs
Summary
PMID 20400705
[Homo sapiens] IL1RL1 acts as a negative regulator of TLR2 signalling whereby over-expression of IL1RL1 can dose-dependently attenuate bacterial lipoprotein (BLP)-induced NF-kappaB activation, but is not required for BLP-induced tolerance.
PMID 20427273
[Homo sapiens] IL1RL1 is the receptor for IL33, a factor shown to modulate tryptase expression in mesenchymal cells (MCs), identifying a novel pathway by which MCs exposed to inflammatory cytokines modulate the phenotype of local MCs to shape their immune responses.
PMID 22922442
[Homo sapiens] IL1RL1 (ST2) pre-treatment suppresses cytokine production and inhibits LPS signalling in dendritic cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115602:
The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:40429570-40465415
Strand Forward strand
Band B
Transcripts
ENSMUST00000097772 ENSMUSP00000095379
ENSMUST00000053043 ENSMUSP00000054914
ENSMUST00000174335 ENSMUSP00000134351
ENSMUST00000173881 ENSMUSP00000134225
ENSMUST00000173514 ENSMUSP00000133784
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002113 interleukin-33 binding
GO:0002114 interleukin-33 receptor activity
GO:0004908 interleukin-1 receptor activity
GO:0005515 protein binding
Biological Process
GO:0002826 negative regulation of T-helper 1 type immune response
GO:0007165 signal transduction
GO:0032689 negative regulation of interferon-gamma production
GO:0032754 positive regulation of interleukin-5 production
GO:0038172 interleukin-33-mediated signaling pathway
GO:0043032 positive regulation of macrophage activation
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0050729 positive regulation of inflammatory response
GO:0090197 positive regulation of chemokine secretion
Cellular Component
GO:0005576 extracellular region
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115602
View Gene Order
ENSBTAG00000018571
Not yet available
Cross-References
SwissProt P14719
TrEMBL G3UYU3 Q5D095
UniProt Splice Variant
Entrez Gene 17082
UniGene Mm.289824
RefSeq NM_001025602 NM_010743 XM_006495741 XM_006495742 XM_006495743 XM_006495744 XM_006495745
OMIM
CCDS CCDS56626 CCDS35548
HPRD
IMGT
MGI ID MGI:98427
MGI Symbol Il1rl1
EMBL AC167126 AC167168 AK033417 BC051445 D13695 M24843 X60184 Y07519
GenPept AAA40160 AAH51445 BAA02854 BAC28277 CAA42742 CAA68812
RNA Seq Atlas 17082

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca