InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rad23b

Summary

InnateDB Gene

IDBG-148611.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rad23b

Gene Name

RAD23b homolog (S. cerevisiae)

Synonyms

0610007D13Rik; AV001138; HR23B; mHR23B; p58

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028426

Encoded Proteins

IDBP-148613

RAD23b homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119318:
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:55350043-55392237

Strand

Forward strand

Band

Transcripts

ENSMUST00000030134	ENSMUSP00000030134
ENSMUST00000127266
ENSMUST00000148719
ENSMUST00000156263

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	22 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0005515	protein binding
GO:0031593	polyubiquitin binding

Biological Process

GO:0000715	nucleotide-excision repair, DNA damage recognition
GO:0006289	nucleotide-excision repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007283	spermatogenesis
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process