Version 5.4
Mus musculus Gene: Tpmt
Summary
InnateDB Gene IDBG-148937.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tpmt
Gene Name thiopurine methyltransferase
Synonyms AW106912
Species Mus musculus
Ensembl Gene ENSMUSG00000021376
Encoded Proteins
IDBP-148939
thiopurine methyltransferase
IDBP-260958
thiopurine methyltransferase
IDBP-535180
thiopurine methyltransferase
IDBP-534979
thiopurine methyltransferase
IDBP-535409
thiopurine methyltransferase
IDBP-541839
thiopurine methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137364:
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. [provided by RefSeq, Jul 2008]
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:47025170-47044737
Strand Reverse strand
Band A5
Transcripts
ENSMUST00000021806 ENSMUSP00000021806
ENSMUST00000110118 ENSMUSP00000105745
ENSMUST00000151509 ENSMUSP00000120564
ENSMUST00000136864 ENSMUSP00000120081
ENSMUST00000154802 ENSMUSP00000121827
ENSMUST00000133100
ENSMUST00000124948 ENSMUSP00000115361
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008119 thiopurine S-methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0033574 response to testosterone
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000137364
View Gene Order
ENSBTAG00000019300
Not yet available
Pathways
NETPATH
REACTOME
REACT_243247
Phase II conjugation pathway
REACT_188937
Metabolism pathway
REACT_241023
Methylation pathway
REACT_232343
Biological oxidations pathway
KEGG
mmu00983
Drug metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6946
Methylation pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_218176
Biological oxidations pathway
REACT_202958
Methylation pathway
REACT_219139
Metabolism pathway
REACT_213008
Phase II conjugation pathway
KEGG
hsa00983
Drug metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D6RIK3
UniProt Splice Variant
Entrez Gene 22017
UniGene Mm.10169
RefSeq NM_016785 XM_006516925 XM_006516926
OMIM
CCDS CCDS26488
HPRD
IMGT
MGI ID MGI:98812
MGI Symbol Tpmt
EMBL AC096628
GenPept
RNA Seq Atlas 22017

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca