InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Foxa3

Summary

InnateDB Gene

IDBG-149068.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxa3

Gene Name

forkhead box A3

Synonyms

Hnf-3g; Hnf3g; Tcf-3g; Tcf3g

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040891

Encoded Proteins

IDBP-149070

forkhead box A3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170608:
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:19013282-19023538

Strand

Reverse strand

Band

Transcripts

ENSMUST00000036018	ENSMUSP00000043173
ENSMUST00000153321

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001678	cellular glucose homeostasis
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007283	spermatogenesis
GO:0007389	pattern specification process
GO:0009267	cellular response to starvation
GO:0009888	tissue development
GO:0010817	regulation of hormone levels
GO:0016568	chromatin modification
GO:0031018	endocrine pancreas development
GO:0045666	positive regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048665	neuron fate specification
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity