Version 5.4
Homo sapiens Gene: CHRNA9
Summary
InnateDB Gene IDBG-14927.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHRNA9
Gene Name cholinergic receptor, nicotinic, alpha 9 (neuronal)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174343
Encoded Proteins
IDBP-14931
cholinergic receptor, nicotinic, alpha 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:40335329-40355217
Strand Forward strand
Band p14
Transcripts
ENST00000310169 ENSP00000312663
ENST00000502377
ENST00000509518
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004889 acetylcholine-activated cation-selective channel activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007268 synaptic transmission
GO:0007605 sensory perception of sound
GO:0042472 inner ear morphogenesis
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005892 acetylcholine-gated channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029205
View Gene Order
ENSBTAG00000015252
Not yet available
Pathways
NETPATH
REACTOME
REACT_13685
Neuronal System pathway
REACT_22149
Postsynaptic nicotinic acetylcholine receptors pathway
REACT_22126
Activation of Nicotinic Acetylcholine Receptors pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_22303
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_15461
Acetylcholine Binding And Downstream Events pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.272278 Hs.614215
RefSeq NM_017581
HUGO
OMIM
CCDS CCDS3459
HPRD 16092
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca