Version 5.4
Mus musculus Gene: Dmpk
Summary
InnateDB Gene IDBG-149384.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dmpk
Gene Name dystrophia myotonica-protein kinase
Synonyms DM; Dm15; DMK; MDPK; MT-PK
Species Mus musculus
Ensembl Gene ENSMUSG00000030409
Encoded Proteins
IDBP-149386
dystrophia myotonica-protein kinase
IDBP-264459
dystrophia myotonica-protein kinase
IDBP-264461
dystrophia myotonica-protein kinase
IDBP-541911
dystrophia myotonica-protein kinase
IDBP-531784
dystrophia myotonica-protein kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a serine/threonine protein kinase that contains coiled-coil and C-terminal membrane association domains. In the embryonic mouse, it is found in cardiac and skeletal myocytes where it appears to play a role in myogenesis. In adults, the transcript is localized to several tissues including brain, heart, and skeletal and smooth muscle, and a function in cytoskeletal remodeling has been described. Transcripts with expanded CUG repeats in the 3\' untranslated region mediate alternative splicing of several genes and sequester RNA binding proteins and RNA transcripts that contain CAG repeats, resulting in myotonic dystrophy, an autosomal dominant neuromuscular disorder. Alternative splicing results in multiple protein coding and non-coding transcript variants. [provided by RefSeq, Oct 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:19083849-19093821
Strand Forward strand
Band A3
Transcripts
ENSMUST00000032568 ENSMUSP00000032568
ENSMUST00000108474 ENSMUSP00000104114
ENSMUST00000108473 ENSMUSP00000104113
ENSMUST00000122999 ENSMUSP00000123516
ENSMUST00000154199 ENSMUSP00000118459
ENSMUST00000149188
ENSMUST00000142725
ENSMUST00000137219
ENSMUST00000135839
ENSMUST00000147215
ENSMUST00000152050
ENSMUST00000128422
ENSMUST00000148472
ENSMUST00000132115
ENSMUST00000143938
ENSMUST00000148380
ENSMUST00000126264
ENSMUST00000140742
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017020 myosin phosphatase regulator activity
GO:0031072 heat shock protein binding
GO:0046872 metal ion binding
Biological Process
GO:0002028 regulation of sodium ion transport
GO:0006468 protein phosphorylation
GO:0006874 cellular calcium ion homeostasis
GO:0006998 nuclear envelope organization
GO:0008016 regulation of heart contraction
GO:0008152 metabolic process
GO:0010657 muscle cell apoptotic process
GO:0010830 regulation of myotube differentiation
GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling
GO:0014853 regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction
GO:0050790 regulation of catalytic activity
GO:0051823 regulation of synapse structural plasticity
Cellular Component
GO:0005640 nuclear outer membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031307 integral component of mitochondrial outer membrane
GO:0031965 nuclear membrane
GO:0033017 sarcoplasmic reticulum membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104936
View Gene Order
ENSBTAG00000013347
Not yet available
Cross-References
SwissProt
TrEMBL D6RI32
UniProt Splice Variant
Entrez Gene 13400
UniGene Mm.6529
RefSeq NM_001190490 NM_001190491 NM_032418 XM_006539518 XM_006539519 XM_006539523
OMIM
CCDS CCDS39794 CCDS52053 CCDS52054
HPRD
IMGT
MGI ID MGI:94906
MGI Symbol Dmpk
EMBL AC145199 AC170864
GenPept
RNA Seq Atlas 13400

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca