InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Msr1

Summary

InnateDB Gene

IDBG-149582.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Msr1

Gene Name

macrophage scavenger receptor 1

Synonyms

MRS-A; MSR; MSR-A; Scara1; Scvr; SR-AI; SR-AII

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025044

Encoded Proteins

IDBP-149584

macrophage scavenger receptor 1

IDBP-627565

macrophage scavenger receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21460221

Msr1 deficiency leads to greater sensitivity to LPS-induced endotoxic shock. Msr1 down-regulates inflammatory gene expression in dendritic cells by suppressing Tlr4-mediated activation of NFKB.

PMID 21756882

Msr1, one of the principal receptors expressed on macrophages, suppresses macrophage activation by inhibiting the binding of lipopolysaccharide (LPS) to Tlr4 in a competitive manner; thus playing a pivotal role in the regulation of the LPS-induced inflammatory response.

PMID 24035364

Autophagy regulates phagocytosis by modulating the expression of scavenger receptors, Marco and Msr1

InnateDB Annotation from Orthologs

Summary

PMID 19914718

[Homo sapiens] MSR1 is required for sensing human cytomegalovirus (HCMV) by endosomal TLR3 and TLR9 in monocytic THP-1 cells.

PMID 20162551

[Homo sapiens] MRS1 (SR-A) is upregulated in TLR4-mediated LPS responses and these receptors contribute to the efficient capturing and clearance of invading microbial pathogens.

PMID 21460221

[Homo sapiens] MSR1 deficiency leads to greater sensitivity to LPS-induced endotoxic shock. MSR1 down-regulates inflammatory gene expression in dendritic cells by suppressing TLR4-mediated activation of NFKB.

PMID 21756882

[Homo sapiens] MSR1, one of the principal receptors expressed on macrophages, suppresses macrophage activation by inhibiting the binding of lipopolysaccharide (LPS) to TLR4 in a competitive manner; thus playing a pivotal role in the regulation of the LPS-induced inflammatory response. (Demonstrated in murine model)

PMID 22751446

[Homo sapiens] Deletion of MSR1 results in protection from septic shock and modulation of TLR4 signalling in peritoneal macrophages. (Demonstrated in mice)

PMID 24257313

[Homo sapiens] MSR1 and Cd36 share several ligands and are involved in largely overlapping physiological and pathological processes, but they differ significantly in their effects on proinflammatory and immunoregulatory functions of macrophages.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000038945:
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer\'s disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:39581700-39642678

Strand

Reverse strand

Band

Transcripts

ENSMUST00000026021	ENSMUSP00000026021
ENSMUST00000170091	ENSMUSP00000132535

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0030169	low-density lipoprotein particle binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0010886	positive regulation of cholesterol storage
GO:0030301	cholesterol transport
GO:0034381	plasma lipoprotein particle clearance
GO:0042953	lipoprotein transport
GO:0045087	innate immune response (InnateDB)
GO:0071407	cellular response to organic cyclic compound

Cellular Component

GO:0005581	collagen trimer
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031410	cytoplasmic vesicle
GO:0034362	low-density lipoprotein particle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000038945

View Gene Order

ENSBTAG00000002885

Not yet available

Pathways

NETPATH

REACTOME

REACT_196573

Binding and Uptake of Ligands by Scavenger Receptors pathway

REACT_196581

Scavenging by Class A Receptors pathway

KEGG

mmu04145

Phagosome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_160300

Binding and Uptake of Ligands by Scavenger Receptors pathway

REACT_163699

Scavenging by Class A Receptors pathway

REACT_209041

Scavenging by Class A Receptors pathway

REACT_213817

Binding and Uptake of Ligands by Scavenger Receptors pathway

KEGG

hsa04145

Phagosome pathway

INOH

PID NCI

Cross-References

SwissProt

P30204

TrEMBL

UniProt Splice Variant

Entrez Gene

20288

UniGene

Mm.239291 Mm.416123

RefSeq

NM_001113326 XM_006509312 NM_031195

OMIM

CCDS

CCDS52542 CCDS52543

HPRD

IMGT

MGI ID

MGI:98257

MGI Symbol

Msr1

EMBL

AC111028 AF203781 AK089178 BC003814 D13382 L04274 L04275 M59445 M59446 U13873

GenPept

AAA37464 AAA37465 AAA39747 AAA39748 AAC13774 AAF14001 AAH03814 BAA02650 BAC40779

RNA Seq Atlas

20288