Version 5.4
Mus musculus Gene: Syne2
Summary
InnateDB Gene IDBG-149682.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Syne2
Gene Name synaptic nuclear envelope 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000063450
Encoded Proteins
IDBP-149686
synaptic nuclear envelope 2
IDBP-149688
synaptic nuclear envelope 2
IDBP-536856
synaptic nuclear envelope 2
IDBP-533273
synaptic nuclear envelope 2
IDBP-541098
synaptic nuclear envelope 2
IDBP-541089
synaptic nuclear envelope 2
IDBP-540687
synaptic nuclear envelope 2
IDBP-538852
synaptic nuclear envelope 2
IDBP-541072
synaptic nuclear envelope 2
IDBP-534614
synaptic nuclear envelope 2
IDBP-533408
synaptic nuclear envelope 2
IDBP-535430
synaptic nuclear envelope 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000054654:
The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:75818134-76110926
Strand Forward strand
Band C3
Transcripts
ENSMUST00000044217 ENSMUSP00000047697
ENSMUST00000085280 ENSMUSP00000082383
ENSMUST00000142864 ENSMUSP00000119268
ENSMUST00000143031 ENSMUSP00000119120
ENSMUST00000133623
ENSMUST00000150317 ENSMUSP00000118142
ENSMUST00000157033
ENSMUST00000148324 ENSMUSP00000121517
ENSMUST00000124685
ENSMUST00000148825 ENSMUSP00000120371
ENSMUST00000139204 ENSMUSP00000118921
ENSMUST00000154762
ENSMUST00000131480 ENSMUSP00000114364
ENSMUST00000154509 ENSMUSP00000116718
ENSMUST00000126903 ENSMUSP00000115053
ENSMUST00000132161 ENSMUSP00000122781
ENSMUST00000151286
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0006998 nuclear envelope organization
GO:0007097 nuclear migration
GO:0007163 establishment or maintenance of cell polarity
GO:0010761 fibroblast migration
GO:0030335 positive regulation of cell migration
GO:0031022 nuclear migration along microfilament
GO:0034504 protein localization to nucleus
GO:0051642 centrosome localization
GO:0090286 cytoskeletal anchoring at nuclear membrane
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005640 nuclear outer membrane
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0016021 integral component of membrane
GO:0016235 aggresome
GO:0016529 sarcoplasmic reticulum
GO:0030016 myofibril
GO:0030018 Z disc
GO:0031258 lamellipodium membrane
GO:0031527 filopodium membrane
GO:0031965 nuclear membrane
GO:0031981 nuclear lumen
GO:0033017 sarcoplasmic reticulum membrane
GO:0034993 SUN-KASH complex
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000054654
View Gene Order
ENSBTAG00000025450
Not yet available
Pathways
NETPATH
REACTOME
REACT_75800
Meiotic Synapsis pathway
REACT_200794
Mus musculus biological processes pathway
REACT_198626
Meiotic synapsis pathway
REACT_188804
Cell Cycle pathway
REACT_198624
Meiosis pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.26652 Mm.402320
RefSeq NM_001005510
OMIM
CCDS CCDS49091
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca