InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gckr

Summary

InnateDB Gene

IDBG-149698.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gckr

Gene Name

glucokinase regulatory protein

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000059434

Encoded Proteins

IDBP-149700

glucokinase regulatory protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000084734:
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:31297581-31327300

Strand

Forward strand

Band

Transcripts

ENSMUST00000072228

ENSMUSP00000072084

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0030246	carbohydrate binding
GO:0070095	fructose-6-phosphate binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0001678	cellular glucose homeostasis
GO:0005975	carbohydrate metabolic process
GO:0009750	response to fructose
GO:0033132	negative regulation of glucokinase activity
GO:0033133	positive regulation of glucokinase activity
GO:0043086	negative regulation of catalytic activity
GO:0046415	urate metabolic process
GO:0070328	triglyceride homeostasis