Version 5.4
Mus musculus Gene: Aff2
Summary
InnateDB Gene IDBG-149821.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aff2
Gene Name AF4/FMR2 family, member 2
Synonyms Fmr2; FMR2P; Ox19; Oxh
Species Mus musculus
Ensembl Gene ENSMUSG00000031189
Encoded Proteins
IDBP-149823
AF4/FMR2 family, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155966:
This gene encodes a putative transcriptional activator that is a member of the AF4\FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked mental retardation. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:69360294-69868037
Strand Forward strand
Band A7.1
Transcripts
ENSMUST00000033532 ENSMUSP00000033532
ENSMUST00000139977
ENSMUST00000143097
ENSMUST00000151662
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002151 G-quadruplex RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0007611 learning or memory
GO:0008380 RNA splicing
GO:0043484 regulation of RNA splicing
Cellular Component
GO:0016607 nuclear speck
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000155966
View Gene Order
ENSBTAG00000020750
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.466576
RefSeq NM_008032 XM_006527820 XM_006527821
OMIM
CCDS CCDS30173
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca