InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ldb3

Summary

InnateDB Gene

IDBG-149830.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ldb3

Gene Name

LIM domain binding 3

Synonyms

AW742271; PDLIM6; ZASP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021798

Encoded Proteins

IDBP-149832

LIM domain binding 3

IDBP-149834

LIM domain binding 3

IDBP-149836

LIM domain binding 3

IDBP-149838

LIM domain binding 3

IDBP-149842

LIM domain binding 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122367:
This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:34526699-34588681

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022327	ENSMUSP00000022327
ENSMUST00000090040	ENSMUSP00000087494
ENSMUST00000064098	ENSMUSP00000066784
ENSMUST00000022328	ENSMUSP00000022328
ENSMUST00000022330	ENSMUSP00000022330

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0008270	zinc ion binding
GO:0051371	muscle alpha-actinin binding

Biological Process

GO:0045214

sarcomere organization

Cellular Component

GO:0005856	cytoskeleton
GO:0030018	Z disc
GO:0031143	pseudopodium
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000122367

View Gene Order

ENSBTAG00000018707

Not yet available

Cross-References

SwissProt

Q9JKS4

TrEMBL

UniProt Splice Variant

Entrez Gene

24131

UniGene

Mm.29733

RefSeq

NM_001039076 NM_001039071 NM_001039072 NM_001039073 NM_001039074 NM_011918 XM_006519017

OMIM

CCDS

CCDS26942 CCDS26940 CCDS26941 CCDS36878 CCDS36879

HPRD

IMGT

MGI ID

MGI:1344412

MGI Symbol

Ldb3

EMBL

AF114378 AF114379 AF228057 AF228058 AJ005621 AK004020 AK137181 AK142292 AK172980 AY206011 AY206012 AY206013 AY206015 BC099596 BC138793 BC145420

GenPept

AAD42950 AAD42951 AAF33847 AAF33848 AAH99596 AAI38794 AAI45421 AAO26187 AAO26188 AAO26189 AAO26190 BAB23128 BAD32258 BAE23262 BAE25016 CAB46747

RNA Seq Atlas

24131