InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP8B3

Summary

InnateDB Gene

IDBG-14989.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP8B3

Gene Name

ATPase, aminophospholipid transporter, class I, type 8B, member 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000130270

Encoded Proteins

IDBP-14991

ATPase, aminophospholipid transporter, class I, type 8B, member 3

IDBP-602224

ATPase, aminophospholipid transporter, class I, type 8B, member 3

IDBP-584162

ATPase, aminophospholipid transporter, class I, type 8B, member 3

IDBP-585093

ATPase, aminophospholipid transporter, class I, type 8B, member 3

IDBP-588190

ATPase, aminophospholipid transporter, class I, type 8B, member 3

IDBP-586905

ATPase, aminophospholipid transporter, class I, type 8B, member 3

IDBP-763026

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to the other. This gene encodes member 3 of phospholipid-transporting ATPase 8B; other members of this protein family are located on chromosomes 1, 15 and 18. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:1782075-1812276

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000310127	ENSP00000311336
ENST00000531925	ENSP00000444334
ENST00000525591	ENSP00000437115
ENST00000526847	ENSP00000439993
ENST00000526092	ENSP00000445204
ENST00000533107
ENST00000533993	ENSP00000445883
ENST00000587160	ENSP00000465027

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004012	phospholipid-translocating ATPase activity
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006812	cation transport
GO:0007339	binding of sperm to zona pellucida
GO:0015914	phospholipid transport
GO:0045332	phospholipid translocation

Cellular Component

GO:0001669	acrosomal vesicle
GO:0002080	acrosomal membrane
GO:0005783	endoplasmic reticulum
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000003341

View Gene Order

ENSBTAG00000020229

Not yet available

Pathways

NETPATH

REACTOME

REACT_25149

Ion transport by P-type ATPases pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

O60423

TrEMBL

UniProt Splice Variant

Entrez Gene

148229

UniGene

Hs.306212 Hs.742213

RefSeq

NM_001178002 XM_006722654 XM_006722655 XM_006722656 NM_138813

HUGO

HGNC:13535

OMIM

605866

CCDS

CCDS54196 CCDS45901

HPRD

05793

IMGT

EMBL

AC004755 AC012615 AK057452 AY302538 BC035162 CH471139

GenPept

AAC17601 AAH35162 AAQ19028 BAB71492 EAW69455

RNA Seq Atlas

102725415 148229