Mus musculus Gene: Vasp | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-149918.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Vasp | ||||||||||||||||||||||
Gene Name | vasodilator-stimulated phosphoprotein | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000030403 | ||||||||||||||||||||||
Encoded Proteins |
vasodilator-stimulated phosphoprotein
|
||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Homo sapiens] VASP is an important component of the cellular microfilament system that plays a major role in the regulation of serum response element (SRE)-dependent transcription. VASP activity is regulated by GMP-dependent protein kinase (G-kinase).
|
||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125753:
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008] |
||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 7:19256929-19271817 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | A3 | ||||||||||||||||||||||
Transcripts |
|
||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||
Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Immune System pathway
Signaling by Robo receptor pathway
Axon guidance pathway
Cell-extracellular matrix interactions pathway
Adaptive Immune System pathway
Developmental Biology pathway
Cell junction organization pathway
Generation of second messenger molecules pathway
Cell-Cell communication pathway
TCR signaling pathway
|
||||||||||||||||||||||
KEGG |
Leukocyte transendothelial migration pathway
Focal adhesion pathway
Fc gamma R-mediated phagocytosis pathway
|
||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
EGFR1 pathway
TCR pathway
BCR pathway
TSH pathway
TSLP pathway
|
||||||||||||||||||||||
REACTOME |
Generation of second messenger molecules pathway
Cell-extracellular matrix interactions pathway
Signaling by Robo receptor pathway
Developmental Biology pathway
Cell-Cell communication pathway
TCR signaling pathway
Cell junction organization pathway
Axon guidance pathway
Adaptive Immune System pathway
Immune System pathway
Immune System pathway
Cell junction organization pathway
Cell-Cell communication pathway
Axon guidance pathway
Adaptive Immune System pathway
Cell-extracellular matrix interactions pathway
Generation of second messenger molecules pathway
Developmental Biology pathway
TCR signaling pathway
Signaling by Robo receptor pathway
|
||||||||||||||||||||||
KEGG |
Leukocyte transendothelial migration pathway
Focal adhesion pathway
Fc gamma R-mediated phagocytosis pathway
|
||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI |
IL8- and CXCR2-mediated signaling events
PAR1-mediated thrombin signaling events
Stabilization and expansion of the E-cadherin adherens junction
E-cadherin signaling in keratinocytes
|
||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.9684 | ||||||||||||||||||||||
RefSeq | NM_001282021 NM_009499 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS52056 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||